Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation

被引:16
作者
Gagat, Maciej [1 ]
Krajewski, Adrian [1 ]
Grzanka, Dariusz [2 ]
Grzanka, Alina [1 ]
机构
[1] Nicolaus Copernicus Univ Torun, Collegium Med Bydgoszcz, Dept Histol & Embryol, 24 Karlowicza St, PL-85092 Bydgoszcz, Poland
[2] Nicolaus Copernicus Univ Torun, Collegium Med Bydgoszcz, Clin Pathomorphol, Fac Med, PL-85092 Bydgoszcz, Poland
关键词
cyclin F; CCNF; ribonucleotide reductase; melanoma; skin cancer; METASTATIC MELANOMA; BREAST-CANCER; MEDIATED DEGRADATION; TRANSFERRIN RECEPTOR; INHIBITOR P27(KIP1); MELANOCYTIC LESIONS; MALIGNANT PHENOTYPE; PROTEIN EXPRESSION; TREATMENT OPTIONS; PROGNOSTIC VALUE;
D O I
10.3892/or.2018.6435
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cyclin F is a part of the Skp, Cullin, F-box containing ligase complex. The activity of cyclin F includes cell cycle control, centrosome duplication and response to DNA damage. The cyclin F expression pattern is very similar to cyclin A, but cyclin F is an orphan cyclin without its cyclin-dependent kinase partner. There is little evidence concerning the role of cyclin F in cancer. In the present study, for the first time, we present analysis from The Cancer Genome Atlas (TCGA) data in the context of expression of cyclin F mRNA in melanoma patients. Our original in silico analysis, not published elsewhere before, revealed that high expression of cyclin F in melanoma patients is associated with worse overall survival. Cyclin F and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival. To shed more light on cyclin F overexpression in melanoma, we analyzed all protein data available in the TCGA melanoma dataset. It was found that in patients with upregulated cyclin F mRNA, we noted increased activity of pathways related to cell cycle and DNA damage repair. These data will support further in vitro and in vivo studies on the involvement of cyclin F in skin cutaneous melanoma.
引用
收藏
页码:123 / 144
页数:22
相关论文
共 55 条
[1]   High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers [J].
Ahlin, Cecilia ;
Lundgren, Claudia ;
Embretsen-Varro, Elin ;
Jirstrom, Karin ;
Blomqvist, Carl ;
Fjallskog, M. -L. .
BREAST CANCER RESEARCH AND TREATMENT, 2017, 164 (03) :667-678
[2]   Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence [J].
Aird, Katherine M. ;
Zhang, Gao ;
Li, Hua ;
Tu, Zhigang ;
Bitler, Benjamin G. ;
Garipov, Azat ;
Wu, Hong ;
Wei, Zhi ;
Wagner, Stephan N. ;
Herlyn, Meenhard ;
Zhang, Rugang .
CELL REPORTS, 2013, 3 (04) :1252-1265
[3]  
Akman A, 2008, INDIAN J DERMATOL VE, V74
[4]   High XRCC1 Protein Expression Is Associated with Poorer Survival in Patients with Head and Neck Squamous Cell Carcinoma [J].
Ang, Mei-Kim ;
Patel, Mihir R. ;
Yin, Xiao-Ying ;
Sundaram, Sneha ;
Fritchie, Karen ;
Zhao, Ni ;
Liu, Yufeng ;
Freemerman, Alex J. ;
Wilkerson, Matthew D. ;
Walter, Vonn ;
Weissler, Mark C. ;
Shockley, William W. ;
Couch, Marion E. ;
Zanation, Adam M. ;
Hackman, Trevor ;
Chera, Bhishamjit S. ;
Harris, Stephen L. ;
Miller, C. Ryan ;
Thorne, Leigh B. ;
Hayward, Michele C. ;
Funkhouser, William K. ;
Olshan, Andrew F. ;
Shores, Carol G. ;
Makowski, Liza ;
Hayes, D. Neil .
CLINICAL CANCER RESEARCH, 2011, 17 (20) :6542-6552
[5]   New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress [J].
Ayuso, Maria I. ;
Hernandez-Jimenez, Macarena ;
Martin, Maria E. ;
Salinas, Matilde ;
Alcazar, Alberto .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) :34355-34363
[6]  
Bales E, 2005, CANCER RES, V65, P692
[7]   Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients [J].
Batar, Bahadir ;
Guven, Gulgun ;
Eroz, Seda ;
Bese, Nuran Senel ;
Guven, Mehmet .
GENE, 2016, 582 (01) :33-37
[8]   Loss of XRCC1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma [J].
Bhandaru, Madhuri ;
Martinka, Magdalena ;
Li, Gang ;
Rotte, Anand .
PIGMENT CELL & MELANOMA RESEARCH, 2014, 27 (03) :366-375
[9]   The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].
Cerami, Ethan ;
Gao, Jianjiong ;
Dogrusoz, Ugur ;
Gross, Benjamin E. ;
Sumer, Selcuk Onur ;
Aksoy, Buelent Arman ;
Jacobsen, Anders ;
Byrne, Caitlin J. ;
Heuer, Michael L. ;
Larsson, Erik ;
Antipin, Yevgeniy ;
Reva, Boris ;
Goldberg, Arthur P. ;
Sander, Chris ;
Schultz, Nikolaus .
CANCER DISCOVERY, 2012, 2 (05) :401-404
[10]   In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes [J].
Chew, Chen Li ;
Lunardi, Andrea ;
Gulluni, Federico ;
Ruan, Daniel T. ;
Chen, Ming ;
Salmena, Leonardo ;
Nishino, Michiya ;
Papa, Antonella ;
Ng, Christopher ;
Fung, Jacqueline ;
Clohessy, John G. ;
Sasaki, Junko ;
Sasaki, Takehiko ;
Bronson, Roderick T. ;
Hirsch, Emilio ;
Pandolfi, Pier Paolo .
CANCER DISCOVERY, 2015, 5 (07) :740-751