Cyanotic congenital heart disease and atherosclerosis

被引：25
作者：
Tarp, Julie Bjerre [1 ,2 ]
Jensen, Annette Schophuus [1 ]
Engstrom, Thomas [1 ]
Holstein-Rathlou, Niels-Henrik [2 ]
Sondergaard, Lars [1 ]
机构：
[1] Copenhagen Univ Hosp, Heart Ctr, Dept Cardiol, Copenhagen, Denmark
[2] Univ Copenhagen, Fac Hlth Sci, Dept Biomed Sci, Copenhagen, Denmark
来源：
HEART | 2017年 / 103卷 / 12期
关键词：
EISENMENGER SYNDROME; SERUM-CHOLESTEROL; HYPOCHOLESTEROLEMIA; MORTALITY; ADULTS; RISK;
D O I：
10.1136/heartjnl-2016-311012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age. Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing. This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.
引用
收藏
页码：897 / 900
页数：4
相关论文
共 35 条
  • [1] Eisenmenger Syndrome A Clinical Perspective in a New Therapeutic Era of Pulmonary Arterial Hypertension
    Beghetti, Maurice
    Galie, Nazzareno
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (09) : 733 - 740
  • [2] RELATION BETWEEN SERUM-CHOLESTEROL AND HEMOGLOBIN VALUES
    BOGA, M
    SZEMERE, PA
    [J]. BRITISH MEDICAL JOURNAL, 1973, 2 (5858) : 119 - 119
  • [3] Extramural coronary arteries in adults with cyanotic congenital heart disease
    Chugh, R
    Perloff, JK
    Fishbein, M
    Child, JS
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (10) : 1355 - 1357
  • [4] Endothelial dysfunction and atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease
    Ciftel, Murat
    Simsek, Ayse
    Turan, Ozlem
    Kardelen, Firat
    Akcurin, Gayaz
    Ertug, Halil
    [J]. ANNALS OF PEDIATRIC CARDIOLOGY, 2012, 5 (02) : 160 - 164
  • [5] Measurement of arterial wall thickness as a surrogate marker for atherosclerosis
    de Groot, E
    Hovingh, GK
    Wiegman, A
    Duriez, P
    Smit, AJ
    Fruchart, JC
    Kastelein, JJP
    [J]. CIRCULATION, 2004, 109 (23) : 33 - 38
  • [6] Survival Prospects and Circumstances of Death in Contemporary Adult Congenital Heart Disease Patients Under Follow-Up at a Large Tertiary Centre
    Diller, Gerhard-Paul
    Kempny, Aleksander
    Alonso-Gonzalez, Rafael
    Swan, Lorna
    Uebing, Anselm
    Li, Wei
    Babu-Narayan, Sonya
    Wort, Stephen J.
    Dimopoulos, Konstantinos
    Gatzoulis, Michael A.
    [J]. CIRCULATION, 2015, 132 (22) : 2118 - 2125
  • [7] Atherosclerosis in Patients With Cyanotic Congenital Heart Disease
    Duffels, Marielle G. J.
    Mulder, Karlijn M.
    Trip, Mieke D.
    de Groot, Erik
    Gort, Johan
    van Dijk, Arie P. J.
    Hoendermis, Elke S.
    Daliento, Luciano
    Zwinderman, Aeiko H.
    Berger, Rolf M. F.
    Mulder, Barbara J. M.
    [J]. CIRCULATION JOURNAL, 2010, 74 (07) : 1436 - 1441
  • [8] Coronary artery ectasia: new insights into pathophysiology, diagnosis, and treatment
    Eitan, Amnon
    Roguin, Ariel
    [J]. CORONARY ARTERY DISEASE, 2016, 27 (05) : 420 - 428
  • [9] Lower Mortality From Coronary Heart Disease and Stroke at Higher Altitudes in Switzerland
    Faeh, David
    Gutzwiller, Felix
    Bopp, Matthias
    [J]. CIRCULATION, 2009, 120 (06) : 495 - 501
  • [10] Pathogenesis of atherosclerosis
    Falk, E
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (08) : C7 - C12
1234