Developmental and cellular functions of the ESCRT machinery in pluricellular organisms

被引：33

作者：

Michelet, Xavier ^{[1
,2
]}

Djeddi, Abderazak ^{[1
,2
]}

Legouis, Renaud ^{[1
,2
]}

机构：

[1] CNRS, FRE3144, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[2] Univ Paris 11, F-91405 Paris, France

来源：

BIOLOGY OF THE CELL | 2010年 / 102卷 / 03期

关键词：

endosomal sorting complexes required for transport (ESCRT); multivesicular body; class E vacuolar protein sorting (VpsE); Mus musculus; Caenorhabditis elegans; Drosophila melanogaster; RECEPTOR DOWN-REGULATION; MULTIVESICULAR BODY FORMATION; ENDOSOME-ASSOCIATED COMPLEX; UBIQUITIN RECOGNITION; SORTING COMPLEX; TSG101; PROTEIN; EAP45-GLUE DOMAIN; MEMBRANE-PROTEINS; STRUCTURAL BASIS; CYCLE ARREST;

D O I：

10.1042/BC20090145

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ESCRTs (endosomal sorting complexes required for transport) were first discovered in yeast and are known to be required in the biogenesis of the MVB (multivesicular body). Most ESCRT research has been carried out in vitro using models such as yeast and mammalian cells in culture. The role of the ESCRTs genes in endosome maturation is conserved from yeast to mammals, but little is known about their function during development in multicellular organisms. Since ESCRTs play a leading role in regulating some cell signalling pathways by addressing receptors to the lysosome, it appears important to monitor ESCRT functions in multicellular models. The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana.

引用

页码：191 / 202

页数：12

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