Enantioselective conjugate additions of organolithiums to BHA enoates mediated by a chiral ligand

被引：41

作者：

Asano, Y ^{[1
]}

Iida, A ^{[1
]}

Tomioka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 60601, Japan

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(97)10366-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conjugate addition reactions of BHA alkenoates with organolithiums in toluene or toluene-hexane at -78 degrees C were mediated by the chiral ligands 1 and 2 to give the corresponding 3-substituted alkanoates in high ees and high yields. The two ligands are complementary each other, 1 is effective for phenyl-and vinyllithiums to give the adducts in 64-93% ee, while 2 is effective for butyl-and ethyllithiums to give the adducts in 91-99% ee. (C) 1997 Elsevier Science Ltd.

引用

页码：8973 / 8976

页数：4

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