RNA maps reveal new RNA classes and a possible function for pervasive transcription

被引：2011

作者：

Kapranov, Philipp

Cheng, Jill

Dike, Sujit

Nix, David A.

Duttagupta, Radharani

Willingham, Aarron T.

Stadler, Peter F.

Hertel, Jana

Hackermueller, Joerg

Hofacker, Ivo L.

Bell, Ian

Cheung, Evelyn

Drenkow, Jorg

Dumais, Erica

Patel, Sandeep

Helt, Gregg

Ganesh, Madhavan

Ghosh, Srinka

Piccolboni, Antonio

Sementchenko, Victor

Tammana, Hari

Gingeras, Thomas R.

机构：

[1] Affymetrix Inc, Affymetrix Lab, Santa Clara, CA 95051 USA

[2] Univ Leipzig, Dept Comp Sci, D-7010 Leipzig, Germany

[3] Univ Vienna, Inst Theoret Chem, A-1010 Vienna, Austria

[4] Fraunhofer Inst Cell Therapy & Immunol, Leipzig, Germany

来源：

SCIENCE | 2007年 / 316卷 / 5830期

关键词：

D O I：

10.1126/science.1138341

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides ( nt) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a novel role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome.

引用

页码：1484 / 1488

页数：5

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