A role for the Wilms' tumor protein WT1 in organ development

被引：46
作者：
Scholz, H [1 ]
Kirschner, KM [1 ]
机构：
[1] Univ Med Berlin, Charite, Johannes Muller Inst Physiol, Berlin, Germany
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00048.2004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Wilms' tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms' tumor 1 (WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.
引用
收藏
页码：54 / 59
页数：6
相关论文
共 46 条
  • [1] THE EXPRESSION OF THE WILMS-TUMOR GENE, WT1, IN THE DEVELOPING MAMMALIAN EMBRYO
    ARMSTRONG, JF
    PRITCHARDJONES, K
    BICKMORE, WA
    HASTIE, ND
    BARD, JBL
    [J]. MECHANISMS OF DEVELOPMENT, 1993, 40 (1-2) : 85 - 97
  • [2] Donor splice-site mutations in WT1 are responsible for Frasier syndrome
    Barbaux, S
    Niaudet, P
    Gubler, MC
    Grunfeld, JP
    Jaubert, F
    Kuttenn, F
    Fekete, CN
    SouleyreauTherville, N
    Thibaud, E
    Fellous, M
    McElreavey, K
    [J]. NATURE GENETICS, 1997, 17 (04) : 467 - 470
  • [3] Beckwith JB, 1998, AM J MED GENET, V79, P268, DOI 10.1002/(SICI)1096-8628(19981002)79:4<268::AID-AJMG7>3.0.CO
  • [4] 2-I
  • [5] A non-AUG translational initiation event generates novel WT1 isoforms
    Bruening, W
    Pelletier, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) : 8646 - 8654
  • [6] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS
    CALL, KM
    GLASER, T
    ITO, CY
    BUCKLER, AJ
    PELLETIER, J
    HABER, DA
    ROSE, EA
    KRAL, A
    YEGER, H
    LEWIS, WH
    JONES, C
    HOUSMAN, DE
    [J]. CELL, 1990, 60 (03) : 509 - 520
  • [7] RNA binding by the Wilms tumor suppressor zinc finger proteins
    Caricasole, A
    Duarte, A
    Larsson, SH
    Hastie, ND
    Little, M
    Holmes, G
    Todorov, I
    Ward, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) : 7562 - 7566
  • [8] Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
    Davies, JA
    Ladomery, M
    Hohenstein, P
    Michael, L
    Shafe, A
    Spraggon, L
    Hastie, N
    [J]. HUMAN MOLECULAR GENETICS, 2004, 13 (02) : 235 - 246
  • [9] WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
    Davies, RC
    Calvio, C
    Bratt, E
    Larsson, SH
    Lamond, AI
    Hastie, ND
    [J]. GENES & DEVELOPMENT, 1998, 12 (20) : 3217 - 3225
  • [10] Truncated WT1 mutants alter the subnuclear localization of the wild-type protein
    Englert, C
    Vidal, M
    Maheswaran, S
    Ge, YM
    Ezzell, RM
    Isselbacher, KJ
    Haber, DA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) : 11960 - 11964
12345