Synthesis, Anti-tumor Activity, and Interaction with DNA of Two Substituted Benzyltin Complexes

Two organotin complexes (C1, C2) were synthesized by di(2,4-dichlorobenzyl)tin dichloride reacting with p-methyl benzoyl hydrazide or p-tert-butyl benzoyl hydrazide, and sodium pyruvate. The structure of the complexes were characterized through elemental analysis, IR, H-1 NMR, C-13 NMR, Sn-119 NMR, HRMS, and X-ray single crystal diffraction. The thermal stability of complexes C1 and C2 were analyzed, and the antitumor activities of the complexes were evaluated by MTT against three cell lines (human lung cancer cells NCI-H460, human liver cancer cells HepG2, and human breast cancer cells MCF7). It was found that complex C1 showed a good inhibitory effect on NCI-H460, HepG2, and MCF7. The interaction of the complexes with DNA was investigated using UV-Vis spectroscopy, fluorescence spectroscopy, and viscosity measurement. It is found that the complexes can bind to DNA through an intercalation mode. CCDC: 2124763, C1; 2124764, C2.