The Generation of Diazo Compounds in Continuous-Flow

被引：69

作者：

Hock, Katharina J. ^{[1
]}

Koenigs, Rene M. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 42期

关键词：

continuous flow; diazo compounds; microreactors; organic synthesis; synthetic methods; IN-SITU GENERATION; TAMING HAZARDOUS CHEMISTRY; CROSS-COUPLING REACTIONS; ETHYL DIAZOACETATE; TUBE REACTOR; TRIFLUOROMETHYL DIAZOMETHANE; CATALYZED CYCLOPROPANATION; SUBSTITUTED CYCLOPROPANES; ORGANIC-SYNTHESIS; BORONIC ACIDS;

D O I：

10.1002/chem.201800136

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Toxic, cancerogenic and explosivethese attributes are typically associated with diazo compounds. Nonetheless, diazo compounds are nowadays a highly demanded class of reagents for organic synthesis, yet the concerns with regards to safe and scalable transformations of these compounds are still exceptionally high. Lately, the research area of the continuous-flow synthesis of diazo compounds attracted significant interest and a whole variety of protocols for their "on-demand" preparation have been realized to date. This concept article focuses on the recent developments using continuous-flow technologies to access diazo compounds; thus minimizing risks and hazards when working with this particular class of compounds. In this article we discuss these concepts and highlight different pre-requisites to access and to perform downstream functionalization reaction.

引用

页码：10571 / 10583

页数：13

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