Synthesis of 1,1-Disubstituted N-Acyl Tetrahydroisoquinolines from Enamides by Cascade Radical Addition and Cyclization

被引：7
作者：
Yu, Hui [1 ]
Xuan, Pengfei [1 ]
Jiao, Mingdong [1 ]
Lin, Jingbo [1 ]
机构：
[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Substainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 33期
关键词：
Radicals; Cyclization; Nitrogen heterocycles; Enamides; Benzylation; ACTIVATED ALKENES; HIGHLY EFFICIENT; ACRYLAMIDES; DERIVATIVES; BENZAMIDES; CARBOTRIFLUOROMETHYLATION; DIFUNCTIONALIZATION; FUNCTIONALIZATION; ALKYLARYLATION; CONSTRUCTION;
D O I：
10.1002/ejoc.201800748
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper(I)-catalyzed radical 1,2-benzylarylation of N-phenethylenamides was developed and 1,1-disubstituted N-acyl tetrahydroisoquinolines were obtained in moderate to good yields. In this process, two new C-C bonds were formed in one-step fashion with high atom economy. A possible reaction pathway for the formation of the products is also discussed.
引用
收藏
页码：4565 / 4570
页数：6
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