BRD4 antagonist-based therapy exerts lethal activity against FLT3 mutation expressing AML cells resistant to FLT3 tyrosine kinase inhibitors

被引:1
|
作者
Rodriguez, Melissa [1 ]
Fiskus, Warren [1 ]
Sharma, Sunil [2 ]
Qi, Jun [3 ]
Schaub, Leasha J. [1 ]
Shah, Bhavin [1 ]
Devaraj, Santhana G. T. [1 ]
Liu, Ka [1 ]
Iyer, Swaminathan [1 ]
Bradner, James E. [3 ]
Bhalla, Kapil N. [1 ]
机构
[1] Houston Methodist Res Inst, Houston, TX USA
[2] Huntsman Canc Inst, Salt Lake City, UT USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
10.1158/1538-7445.AM2014-1721
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1721
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Characterization of dual resistant AML cells to FLT3 inhibitors
    Katayama, Kazuhiro
    CANCER SCIENCE, 2023, 114 : 1482 - 1482
  • [2] Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
    Jiang, JR
    Paez, JG
    Lee, JC
    Bo, RH
    Stone, RM
    DeAngelo, DJ
    Galinsky, I
    Wolpin, BM
    Jonasova, A
    Herman, P
    Fox, EA
    Boggon, TJ
    Eck, MJ
    Weisberg, E
    Griffin, JD
    Gilliland, DG
    Meyerson, M
    Sellers, WR
    BLOOD, 2004, 104 (06) : 1855 - 1858
  • [3] BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD
    Fiskus, Warren
    Sharma, Sunil
    Qi, Jun
    Shah, Bhavin
    Devaraj, Santhana G. T.
    Leveque, Christopher
    Portier, Bryce P.
    Iyer, Swaminathan
    Bradner, James E.
    Bhalla, Kapil N.
    MOLECULAR CANCER THERAPEUTICS, 2014, 13 (10) : 2315 - 2327
  • [4] Dual inhibition of Flt3 and Fes tyrosine kinases potently blocks proliferation of AML cells expressing an active Flt3 mutant.
    Weir, Mark
    Hellwig, Sabine
    Gray, Nathanael S.
    Smithgall, Thomas E.
    CLINICAL CANCER RESEARCH, 2015, 21
  • [5] Disruption of Wnt/β-Catenin Signaling Exerts Antileukemia Activity and Sensitizes with Tyrosine Kinase Inhibitors in FLT3 Mutated AML In Vivo
    Jiang, Xuejie
    Mak, Po Yee
    Mu, Hong
    Mak, Duncan
    Zhang, Qi
    Konopleva, Marina
    Andreeff, Michael
    Carter, Bing Z.
    BLOOD, 2016, 128 (22)
  • [6] The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML cells expressing a constitutively activated FLT3
    Dirschinger, RJ
    Schwab, R
    Faber, F
    Buske, C
    Schnittger, S
    Kelly, LM
    Gilliland, DG
    Hiddemann, W
    Spiekermann, K
    EUROPEAN JOURNAL OF CANCER, 2002, 38 : S83 - S84
  • [7] FLT3 Tyrosine Kinase Inhibitors for the Treatment of Fit and Unfit Patients with FLT3-Mutated AML: A Systematic Review
    Loschi, Michael
    Sammut, Rinzine
    Chiche, Edmond
    Cluzeau, Thomas
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
  • [8] Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition
    Zhu, Ruiqi
    Shirley, Courtney M.
    Chu, S. Haihua
    Li, Li
    Nguyen, Bao H.
    Seo, Jaesung
    Wu, Min
    Seale, Tessa
    Duffield, Amy S.
    Staudt, Louis M.
    Levis, Mark
    Hu, Yu
    Small, Donald
    LEUKEMIA, 2024, 38 (07) : 1581 - 1591
  • [9] Inhibition of NOTCH4 Sensitizes FLT3/ITD Acute Myeloid Leukemia Cells to FLT3 Tyrosine Kinase Inhibition
    Zhu, Ruiqi
    Shirley, Courtney
    Chu, Haihua
    Li, Li
    Bao Nguyen
    Seo, Jaesung
    Seale, Tessa
    Duffield, Amy
    Staudt, Louis M.
    Levis, Mark J.
    Hu, Yu
    Small, Donald
    BLOOD, 2023, 142
  • [10] Arsenic Trioxide Synergizes with FLT3 Tyrosine Kinase Inhibitors to Kill FLT3-ITD+ Leukemic Cells through Depressed Production and Degradation of FLT3 Protein
    Nagai, Kozo
    Hou, Lihong
    Li, Li
    Bao Nguyen
    Shirley, Courtney M.
    Ma, Hayley S.
    Levis, Mark J.
    Duffield, Amy S.
    Small, Donald
    BLOOD, 2016, 128 (22)