Methods for monitoring signaling molecules in cellular compartments

被引：8

作者：

Agetsuma, Masakazu ^{[1
,2
]}

Matsuda, Tomoki ^{[1
]}

Nagai, Takeharu ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Mihogaoka 8-1, Ibaraki, Osaka 5670047, Japan

[2] Japan Sci & Technol Agcy, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

来源：

CELL CALCIUM | 2017年 / 64卷

关键词：

Bioimaging; FRET; pH sensitivity; Super resolution microscopy; Bioluminescent protein; Optogenetics; INFRARED FLUORESCENT PROTEINS; IN-VIVO; CA2+ INDICATORS; LUMINESCENT PROTEINS; CALCIUM INDICATORS; NEURONAL-ACTIVITY; EXPANDED PALETTE; RESOLUTION LIMIT; NEURAL ACTIVITY; OPTICAL CONTROL;

D O I：

10.1016/j.ceca.2016.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells, irrespective of whether they are from multicellular or single-celled organisms, must communicate with the external environment through dynamic regulation of their internal metabolism, which are critical for their survival. Fluorescent and bioluminescent proteins, and related genetic engineering technologies, have provided new opportunities to investigate the molecular dynamics of cells and their internal compartments, with high spatio-temporal resolution. In this review article, since there is a sufficient number of previous reviews summarizing the history of their development and the techniques behind them, here we will focus on molecular features or technologies that have the potential to further open novel investigations of cellular and subcellular dynamics. (C) 2016 The Authors. Published by Elsevier Ltd.

引用

页码：12 / 19

页数：8

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