Measuring brain chemistry using genetically encoded fluorescent sensors

被引：15

作者：

Andreoni, Alessio ^{[1
]}

Davis, Carolyn M. O. ^{[1
]}

Tian, Lin ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Davis, CA 95616 USA

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2019年 / 12卷

基金：

美国国家卫生研究院;

关键词：

Molecular imaging; Neurotransmitter; Neuromodulators; Fluorescent protein; Genetically encoded fluorescent indicators; GPCRs;

D O I：

10.1016/j.cobme.2019.09.008

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To understand the precise roles of chemical messengers in the brain for communication, we need tools to measure the concentration and release events of neurotransmitters and neuromodulators with great precision. Fluorescent protein-based biosensors with high molecular specificity have been recently developed for direct, optical recording of brain chemistry. Here, we discuss the engineering and applications of the most recently developed genetically encoded neuromodulator sensors for in vivo studies.

引用

页码：59 / 67

页数：9

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