Possible oscillatory behavior in p53-mdm2 interaction computer simulation

被引：38
作者：
Mihalas, GI
Simon, Z
Balea, G
Popa, E
机构：
[1] Univ Med & Pharm, Dept Biophys & Med Informat, Timisoara 1900, Romania
[2] West Univ, Timisoara 1900, Romania
来源：
JOURNAL OF BIOLOGICAL SYSTEMS | 2000年 / 8卷 / 01期
关键词：
computer simulation; interconnected genes; oscillations; p53; mdm2;
D O I：
10.1142/S0218339000000031
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Specific activator and repressor transcription factors, which bind to specific regulator DNA sequences, play an important role in gene activity control. Interactions between genes coding such transcription factors should explain the different stable or, sometimes, oscillatory gene activities characteristic for different tissues. A set of models has been built for several systems with interconnected genes and the results of the simulations performed for the p53-mdm2 are here presented and discussed.
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页码：21 / 29
页数：9
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