Neutrophil-to-lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schonlein purpura

被引:33
|
作者
Hong, Seung Hee [1 ]
Kim, Chan Jong [1 ]
Yang, Eun Mi [1 ]
机构
[1] Chonnam Natl Univ Hosp, Dept Pediat, 42 Jebong Ro, Gwangju, South Korea
基金
新加坡国家研究基金会;
关键词
children; gastrointestinal bleeding; Henoch-Schonlein purpura; lymphocyte; neutrophil; SYSTEMIC INFLAMMATION; RENAL INVOLVEMENT; EXPERIENCE; RISK;
D O I
10.1111/ped.13652
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundHenoch-Schonlein purpura (HSP) is a common form of vasculitis in children. It typically involves small vessels of the skin, the gastrointestinal (GI) tract, joints, and kidneys. GI involvement is the most severe short-term complication and GI bleeding is a major complication of HSP, but there is no established predictive marker of GI bleeding. Blood neutrophil-to-lymphocyte ratio (NLR) has been proposed as a potentially useful marker of clinical outcome in diseases with an inflammatory component. The aim of this study was to clarify the association of NLR with HSP and investigate the usefulness of NLR as a marker to predict GI bleeding in children with HSP. MethodsAll patients with newly diagnosed HSP were reviewed retrospectively. White blood cell count, hemoglobin, platelet counts, mean platelet volume, neutrophil and lymphocyte count were evaluated. NLR and platelet-to-lymphocyte ratio (PLR) were calculated using complete blood count data. ResultsThis study involved 141 HSP patients. GI involvement was found in 65 patients (46.1%), and, of these, 15 (10.6%) had GI bleeding. At the time of diagnosis, NLR was significantly higher (P = 0.001) and PLR significantly lower (P = 0.032) in patients with GI bleeding than in those without GI bleeding. On logistic regression analysis, NLR was the only independent predictor of GI bleeding (P = 0.004). The optimal cut-off of NLR for predicting GI bleeding was 2.86 (sensitivity, 73%; specificity, 68%). ConclusionsNLR, a simple and easily obtainable parameter, is a potential predictive marker of GI bleeding in children with HSP.
引用
收藏
页码:791 / 795
页数:5
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