Rosacea: skin innate immunity gone awry?

被引：48
作者：
Bevins, Charles L. [1 ]
Liu, Fu-Tong
机构：
[1] Univ Calif Davis, Dept Microbiol, Sch Med, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Immunol, Sch Med, Davis, CA 95616 USA
[3] Univ Calif Davis, Grad Grp Immunol, Davis, CA 95616 USA
[4] Univ Calif Davis, Grad Grp Immunol, Davis, CA 95817 USA
[5] Univ Calif Davis, Dept Dermatol, Sch Med, Davis, CA 95817 USA
来源：
NATURE MEDICINE | 2007年 / 13卷 / 08期
关键词：
D O I：
10.1038/nm0807-904
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975-981).
引用
收藏
页码：904 / 906
页数：4
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共 13 条
  • [1] Chemically modified tetracyclines as inhibitors of matrix metalloproteinases
    Acharya, MR
    Venitz, E
    Figg, WD
    Sparreboom, A
    [J]. DRUG RESISTANCE UPDATES, 2004, 7 (03) : 195 - 208
  • [2] House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: The cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1
    Asokananthan, N
    Graham, PT
    Stewart, DJ
    Bakker, AJ
    Eidne, KA
    Thompson, PJ
    Stewart, GA
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (08) : 4572 - 4578
  • [3] House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors
    Brown, A
    Farmer, K
    MacDonald, L
    Kalsheker, N
    Pritchard, D
    Haslett, C
    Lamb, J
    Sallenave, JM
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 29 (03) : 381 - 389
  • [4] Rosacea: An update
    Buechner, SA
    [J]. DERMATOLOGY, 2005, 210 (02) : 100 - 108
  • [5] Protease-activated receptor signaling increases epithelial antimicrobial peptide expression
    Chung, WO
    Hansen, SR
    Rao, D
    Dale, BA
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 173 (08) : 5165 - 5170
  • [6] Rosacea: I. Etiology, pathogenesis, and subtype classification
    Crawford, GH
    Pelle, MT
    James, WD
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (03) : 327 - 341
  • [7] Microbial ecology of human skin in health and disease
    Fredricks, DN
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2001, 6 (03) : 167 - 169
  • [8] An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
    Koczulla, R
    von Degenfeld, G
    Kupatt, C
    Krötz, F
    Zahler, S
    Gloe, T
    Issbrüicker, K
    Unterberger, P
    Zaiou, M
    Lebherz, C
    Karl, A
    Raake, P
    Pfosser, A
    Boekstegers, P
    Welsch, U
    Hiemstra, PS
    Vogelmeier, C
    Gallo, RL
    Clauss, M
    Bals, R
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (11) : 1665 - 1672
  • [9] Capillaropathy and capillaroneogenesis in the pathogenesis of rosacea
    Neumann, E
    Frithz, A
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 1998, 37 (04) : 263 - 266
  • [10] Innate antimicrobial peptide protects the skin from invasive bacterial infection
    Nizet, V
    Ohtake, T
    Lauth, X
    Trowbridge, J
    Rudisill, J
    Dorschner, RA
    Pestonjamasp, V
    Piraino, J
    Huttner, K
    Gallo, RL
    [J]. NATURE, 2001, 414 (6862) : 454 - 457
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