microRNAs and EMT in Mammary Cells and Breast Cancer

被引：69
作者：
Wright, Josephine A. [1 ]
Richer, Jennifer K. [2 ]
Goodall, Gregory J. [1 ,3 ]
机构：
[1] SA Pathol, Ctr Canc Biol, Adelaide, SA 5000, Australia
[2] Univ Colorado, Dept Pathol, Aurora, CO 80045 USA
[3] Univ Adelaide, Dept Med, Adelaide, SA 5005, Australia
来源：
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2010年 / 15卷 / 02期
关键词：
microRNA; Epithelial to mesenchymal transition; Mammary cells; Breast cancer; ESTROGEN-RECEPTOR-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; E-CADHERIN; MIR-200; FAMILY; STEM-CELLS; TGF-BETA; DUCTAL CARCINOMA; DOWN-REGULATION; MESSENGER-RNA;
D O I：
10.1007/s10911-010-9183-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.
引用
收藏
页码：213 / 223
页数：11
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