Development of CD1d-restricted NKT cells in the mouse thymus

被引：37
|
作者：
Dao, T
Guo, DL
Ploss, A
Stolzer, A
Saylor, C
Boursalian, TE
Im, JS
Sant'Angelo, DB
机构：
[1] Mem Sloan Kettering Canc Ctr, Lab T Cell Immunobiol, Program Immunol, New York, NY 10021 USA
[2] Cornell Univ, Weill Grad Sch Med Sci, Ithaca, NY 14853 USA
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA
[4] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
[5] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 12期
关键词：
iNKT cells; T cell receptor; thymus; CD1d;
D O I：
10.1002/eji.200425546
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.
引用
收藏
页码：3542 / 3552
页数：11
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