Development of CD1d-restricted NKT cells in the mouse thymus

被引：37

作者：

Dao, T

Guo, DL

Ploss, A

Stolzer, A

Saylor, C

Boursalian, TE

Im, JS

Sant'Angelo, DB

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab T Cell Immunobiol, Program Immunol, New York, NY 10021 USA

[2] Cornell Univ, Weill Grad Sch Med Sci, Ithaca, NY 14853 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, Program Immunol, New York, NY 10021 USA

[5] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 12期

关键词：

iNKT cells; T cell receptor; thymus; CD1d;

D O I：

10.1002/eji.200425546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.

引用

页码：3542 / 3552

页数：11

共 48 条

[1] DEFECTIVE T-CELL RECEPTOR SIGNALING IN MICE LACKING THE THYMIC ISOFORM OF P59(FYN) [J].