Circulating miRNAs in Ageing and Ageing-Related Diseases

被引：75

作者：

Jung, Hwa Jin ^{[1
]}

Suh, Yousin ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Genet & Med, Bronx, NY 11363 USA

[2] Guangdong Med Coll, Ageing Res Inst, Dongguan 523808, Peoples R China

来源：

JOURNAL OF GENETICS AND GENOMICS | 2014年 / 41卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Circulating miRNAs; Ageing; Ageing-related disease; Biomarkers; ACUTE MYOCARDIAL-INFARCTION; ALZHEIMERS-DISEASE; DIAGNOSTIC BIOMARKERS; MICRORNA SIGNATURES; OVARIAN-CANCER; MESSENGER-RNA; PLASMA; CELLS; MICROVESICLES; TARGETS;

D O I：

10.1016/j.jgg.2014.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles (MVs), or in complex with other factors such as RNA-binding proteins and high-density lipoprotein (HDL) particles. These cell-free, circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells. Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases. We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets.

引用

页码：465 / 472

页数：8

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