Metabolomics and Lipidomics Profiling Reveals Hypocholesterolemic and Hypolipidemic Effects of Arabinoxylan on Type 2 Diabetic Rats

被引：54

作者：

Nie, Qixing ^{[1
]}

Xing, Mengmeng ^{[2
]}

Chen, Haihong ^{[1
]}

Hu, Jielun ^{[1
]}

Nie, Shaoping ^{[1
]}

机构：

[1] Nanchang Univ, China Canada Joint Lab Food Sci & Technol Nanchan, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

[2] Shenzhen Longgang Dist Matern & Child Healthcare, Shenzhen 518100, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2019年 / 67卷 / 38期

基金：

中国国家自然科学基金;

关键词：

arabinoxylan; lipidomics; metabolomics; serum; type; 2; diabetes; PLANTAGO-ASIATICA L; INSULIN-RESISTANCE; FATTY-ACIDS; LIPIDS; POLYSACCHARIDE; POPULATION; OBESE; HDL;

D O I：

10.1021/acs.jafc.9b03430

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Type 2 diabetes (T2D) is a pandemic disease chiefly characterized by hyperglycemia. In this study, the combination of serum lipidomic and metabolomic approach was employed to investigate the effect of arabinoxylan on type 2 diabetic rats and identify the critical biomarkers of T2D. Metabolomics analysis revealed that branched-chain amino acids, 12 alpha-hydroxylated bile acids, ketone bodies, and several short- and long-chain acylcarnitines were significantly increased in T2D, whereas lysophosphatidylcholines (LPCs) were significantly decreased. Lipidomics analysis indicated T2D-related dyslipidemia was mainly associated with the increased levels of acetylcarnitine, free fatty acids (FFA), diacylglycerols, triacylglycerols, and cholesteryl esters and the decreased levels of some unsaturated phosphatidylcholines (less than 22 carbons). These variations indicated the disturbed amino acid and lipid metabolism in T2D, and the accumulation of incompletely oxidized lipid species might eventually contribute to impaired insulin action and glucose homeostasis. Arabinoxylan treatment decreased the concentrations of 12 alpha-hydroxylated bile acids, carnitines, and FFAs and increased the levels of LPCs. The improved bile acid and lipid metabolism by arabinoxylan might be involved in the alleviation of hypercholesterolemia and hyperlipidemia in T2D.

引用

页码：10614 / 10623

页数：10

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