Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus

被引：47

作者：

Devlin, Joanne M. ^{[1
]}

Viejo-Borbolla, Abel ^{[2
,3
]}

Browning, Glenn F. ^{[1
]}

Noormohammadi, Amir H. ^{[1
]}

Gilkerson, James R. ^{[1
]}

Alcami, Antonio ^{[2
,3
,4
]}

Hartley, Carol A. ^{[1
]}

机构：

[1] Univ Melbourne, Sch Vet Sci, Melbourne, Vic 3010, Australia

[2] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[3] Univ Autonoma Madrid, Madrid, Spain

[4] Univ Cambridge, Dept Med, Addenbrookes Hosp, Cambridge CB2 2QQ, England

来源：

VACCINE | 2010年 / 28卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

Glycoprotein G; Alphaherpesvirus; Chemokine-binding protein; IN-VIVO; MYCOPLASMA-GALLISEPTICUM; BINDING DOMAIN; CHEMOKINES; CHICKEN; PROTEIN; GENE; CYTOKINES; VIRULENCE; ANTIBODY;

D O I：

10.1016/j.vaccine.2009.11.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes severe respiratory disease in poultry. Glycoprotein G (gG) is a virulence factor in ILTV. Recent studies have shown that gG-deficient ILTV is an effective attenuated vaccine however the function of ILTV gG is unknown. This study examined the function and in vivo relevance of ILTV gG. The results showed that ILTV gG binds to chemokines with high affinity and inhibits leukocyte chemotaxis. Specific-pathogen-free (SPF) chickens infected with gG-deficient virus had altered tracheal leukocyte populations and lower serum antibody levels compared with those infected with the parent virus. The findings suggest that the absence of chemokine-binding activity during infection with gG-deficient ILTV results in altered host immune responses. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1325 / 1332

页数：8

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