Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus

被引：46
作者：
Devlin, Joanne M. [1 ]
Viejo-Borbolla, Abel [2 ,3 ]
Browning, Glenn F. [1 ]
Noormohammadi, Amir H. [1 ]
Gilkerson, James R. [1 ]
Alcami, Antonio [2 ,3 ,4 ]
Hartley, Carol A. [1 ]
机构：
[1] Univ Melbourne, Sch Vet Sci, Melbourne, Vic 3010, Australia
[2] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
[3] Univ Autonoma Madrid, Madrid, Spain
[4] Univ Cambridge, Dept Med, Addenbrookes Hosp, Cambridge CB2 2QQ, England
来源：
VACCINE | 2010年 / 28卷 / 05期
基金：
澳大利亚研究理事会;
关键词：
Glycoprotein G; Alphaherpesvirus; Chemokine-binding protein; IN-VIVO; MYCOPLASMA-GALLISEPTICUM; BINDING DOMAIN; CHEMOKINES; CHICKEN; PROTEIN; GENE; CYTOKINES; VIRULENCE; ANTIBODY;
D O I：
10.1016/j.vaccine.2009.11.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes severe respiratory disease in poultry. Glycoprotein G (gG) is a virulence factor in ILTV. Recent studies have shown that gG-deficient ILTV is an effective attenuated vaccine however the function of ILTV gG is unknown. This study examined the function and in vivo relevance of ILTV gG. The results showed that ILTV gG binds to chemokines with high affinity and inhibits leukocyte chemotaxis. Specific-pathogen-free (SPF) chickens infected with gG-deficient virus had altered tracheal leukocyte populations and lower serum antibody levels compared with those infected with the parent virus. The findings suggest that the absence of chemokine-binding activity during infection with gG-deficient ILTV results in altered host immune responses. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1325 / 1332
页数：8
相关论文
共 29 条
  • [1] Viral mimicry of cytokines, chemokines and their receptors
    Alcami, A
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) : 36 - 50
  • [2] A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus
    Alejo, A
    Ruiz-Argüello, MB
    Ho, Y
    Smith, VP
    Saraiva, M
    Alcami, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) : 5995 - 6000
  • [3] Avian infectious laryngotracheitis
    Bagust, TJ
    Jones, RC
    Guy, JS
    [J]. REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES, 2000, 19 (02): : 483 - 492
  • [4] Glycoprotein G isoforms from some alpha herpesviruses function as broad-spectrum chemokine binding proteins
    Bryant, NA
    Davis-Poynter, N
    Vanderplasschen, A
    Alcami, A
    [J]. EMBO JOURNAL, 2003, 22 (04) : 833 - 846
  • [5] Both soluble and membrane-anchored forms of Felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokine-binding protein
    Costes, B
    Ruiz-Argüello, MB
    Bryant, NA
    Alcami, A
    Vanderplasschen, A
    [J]. JOURNAL OF GENERAL VIROLOGY, 2005, 86 : 3209 - 3214
  • [6] Felid herpesvirus 1 glycoprotein G is a structural protein that mediates the binding of chemokines on the viral envelope
    Costes, Berenice
    Thirion, Muriel
    Dewals, Benjamin
    Mast, Jan
    Ackermann, Mathias
    Markine-Goriaynoff, Nicolas
    Gillet, Laurent
    Vanderplasschen, Alain
    [J]. MICROBES AND INFECTION, 2006, 8 (11) : 2657 - 2667
  • [7] Comparison of the safety and protective efficacy of vaccination with glycoprotein-G-deficient infectious laryngotracheitis virus delivered via eye-drop, drinking water or aerosol
    Devlin, J. M.
    Browning, G. F.
    Gilkerson, J. R.
    Fenton, S. P.
    Hartley, C. A.
    [J]. AVIAN PATHOLOGY, 2008, 37 (01) : 83 - 88
  • [8] Glycoprotein G is a virulence factor in infectious laryngotracheitis virus
    Devlin, J. M.
    Browning, G. F.
    Hartley, C. A.
    Kirkpatrick, N. C.
    Mahmoudian, A.
    Noormohammadi, A. H.
    Gilkerson, J. R.
    [J]. JOURNAL OF GENERAL VIROLOGY, 2006, 87 : 2839 - 2847
  • [9] A glycoprotein I- and glycoprotein E-deficient mutant of infectious laryngotracheitis virus exhibits impaired cell-to-cell spread in cultured cells
    Devlin, JM
    Browning, GF
    Gilkerson, JR
    [J]. ARCHIVES OF VIROLOGY, 2006, 151 (07) : 1281 - 1289
  • [10] Glycoprotein G deficient infectious laryngotracheitis virus is a candidate attenuated vaccine
    Devlin, Joanne M.
    Browning, Glenn F.
    Hartley, Carol A.
    Gilkerson, James R.
    [J]. VACCINE, 2007, 25 (18) : 3561 - 3566
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