Immune cells may fend off Alzheimer disease

被引:42
作者
Britschgi, Markus [1 ]
Wyss-Coray, Tony
机构
[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Palo Alto, CA 94304 USA
关键词
D O I
10.1038/nm0407-408
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chemokines in the brain recruit immune cells from the blood or from within the brain. Disrupting this line of communication exacerbates disease in mouse models of Alzheimer disease (pages 432-438).
引用
收藏
页码:408 / 409
页数:3
相关论文
共 13 条
[1]   Inflammation and Alzheimer's disease [J].
Akiyama, H ;
Barger, S ;
Barnum, S ;
Bradt, B ;
Bauer, J ;
Cole, GM ;
Cooper, NR ;
Eikelenboom, P ;
Emmerling, M ;
Fiebich, BL ;
Finch, CE ;
Frautschy, S ;
Griffin, WST ;
Hampel, H ;
Hull, M ;
Landreth, G ;
Lue, LF ;
Mrak, R ;
Mackenzie, IR ;
McGeer, PL ;
O'Banion, MK ;
Pachter, J ;
Pasinetti, G ;
Plata-Salaman, C ;
Rogers, J ;
Rydel, R ;
Shen, Y ;
Streit, W ;
Strohmeyer, R ;
Tooyoma, I ;
Van Muiswinkel, FL ;
Veerhuis, R ;
Walker, D ;
Webster, S ;
Wegrzyniak, B ;
Wenk, G ;
Wyss-Coray, T .
NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421
[2]   Alzheimer's disease [J].
Blennow, Kaj ;
de Leon, Mony J. ;
Zetterberg, Henrik .
LANCET, 2006, 368 (9533) :387-403
[3]   Mechanisms of disease - The many roles of chemokines and chemokine receptors in inflammation [J].
Charo, IF ;
Ransohoff, RM .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :610-621
[4]   Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease [J].
El Khoury, Joseph ;
Toft, Michelle ;
Hickman, Suzanne E. ;
Means, Terry K. ;
Terada, Kinya ;
Geula, Changiz ;
Luster, Andrew D. .
NATURE MEDICINE, 2007, 13 (04) :432-438
[5]   Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice [J].
Huang, DR ;
Wujek, J ;
Kidd, G ;
He, TT ;
Cardona, A ;
Sasse, ME ;
Stein, EJ ;
Kish, J ;
Tani, M ;
Charo, IF ;
Proudfoot, AE ;
Rollins, BJ ;
Handel, T ;
Ransohoff, RM .
FASEB JOURNAL, 2005, 19 (07) :761-772
[6]   Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma:: Suppression leads to biochemical and pathological deposition [J].
Iwata, N ;
Tsubuki, S ;
Takaki, Y ;
Watanabe, K ;
Sekiguchi, M ;
Hosoki, E ;
Kawashima-Morishima, M ;
Lee, HJ ;
Hama, E ;
Sekine-Aizawa, Y ;
Saido, TC .
NATURE MEDICINE, 2000, 6 (02) :143-150
[7]   Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death [J].
Leissring, MA ;
Farris, W ;
Chang, AY ;
Walsh, DM ;
Wu, XN ;
Sun, XY ;
Frosch, MP ;
Selkoe, DJ .
NEURON, 2003, 40 (06) :1087-1093
[8]   Aβ42 is essential for parenchymal and vascular amyloid deposition in mice [J].
McGowan, E ;
Pickford, F ;
Kim, J ;
Onstead, L ;
Eriksen, J ;
Yu, C ;
Skipper, L ;
Murphy, MP ;
Beard, J ;
Das, P ;
Jansen, K ;
DeLucia, M ;
Lin, WL ;
Dolios, G ;
Wang, R ;
Eckman, CB ;
Dickson, DW ;
Hutton, M ;
Hardy, J ;
Golde, T .
NEURON, 2005, 47 (02) :191-199
[9]   Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details [J].
Rebenko-Moll, Natalia M. ;
Liu, LiPing ;
Cardona, Astrid ;
Ransohoff, Richard M. .
CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (06) :683-689
[10]   Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease [J].
Simard, AR ;
Soulet, D ;
Gowing, G ;
Julien, JP ;
Rivest, S .
NEURON, 2006, 49 (04) :489-502