APC, signal transduction and genetic instability in colorectal cancer

被引：729
作者：
Fodde, R
Smits, R
Clevers, H
机构：
[1] Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2300 RA Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Ctr Biomed Genet, NL-2300 RA Leiden, Netherlands
[3] Univ Utrecht, Med Ctr, Dept Immunol, NL-3508 GA Utrecht, Netherlands
[4] Univ Utrecht, Med Ctr, Ctr Biomed Genet, NL-3508 GA Utrecht, Netherlands
来源：
NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期
关键词：
D O I：
10.1038/35094067
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC the gene responsible for most cases of colorectal cancer - might fulfil both requirements.
引用
收藏
页码：55 / 67
页数：13
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