Photodynamic Activity of Liposomal Photosensitizers via Energy Transfer from Antenna Molecules to [60]Fullerene

被引：39

作者：

Ikeda, Atsushi ^{[1
]}

Akiyama, Motofusa ^{[1
]}

Ogawa, Takuya ^{[2
]}

Takeya, Tatsuo ^{[2
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300129, Japan

[2] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300129, Japan

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2010年 / 1卷 / 03期

基金：

日本学术振兴会;

关键词：

Energy transfer; fullerenes; photodynamic therapy; photosensitizers; liposomes; FULLERENE DERIVATIVES; SINGLET OXYGEN; THERAPY; WATER; C-60; CANCER; DYES;

D O I：

10.1021/ml100021x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Photodynamic therapy (PDT) is an emerging approach for the treatment of tumor diseases that has received growing interest in the past few years. In this study, we constructed liposomal photosensitizers (PS) for PDT by shoehorning as light-harvesting "antenna" molecules and dense [60]fullerene (C-60) into lipid membrane bilayers. The liposomal PS showed improved photodynamic activity toward human cancer cells via the photoenergy transfer from photoactivated antenna molecules to C-60.

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收藏

页码：115 / 119

页数：5

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