Heterogeneity of hepatitis B transmission in Tunisia: Risk factors for infection and chronic carriage before the introduction of a universal vaccine program

被引：14

作者：

Ben-Alaya-Bouafif, Nissaf ^{[1
]}

Bahri, Olfa ^{[2
]}

Chlif, Sadok ^{[1
]}

Bettaieb, Jihene ^{[1
]}

Toumi, Amine ^{[1
]}

Haj, Hamida Nabil Bel ^{[1
]}

Zaatour, Amor ^{[1
]}

Gharbi, Adel ^{[1
]}

Dellagi, Koussay ^{[3
]}

Triki, Hinda ^{[2
]}

Ben Salah, Afif ^{[1
]}

机构：

[1] Pasteur Inst Tunis, Lab Med Epidemiol, Tunis 1003, Tunisia

[2] Pasteur Inst Tunis, Lab Clin Virol, Tunis 1003, Tunisia

[3] Pasteur Inst Tunis, Lab Immunopathol Vaccinol & Mol Genet, Tunis 1003, Tunisia

来源：

VACCINE | 2010年 / 28卷 / 19期

关键词：

HBV infection; Chronic carriage; Intrafamilial transmission; VIRUS-INFECTION; HORIZONTAL TRANSMISSION; HBV INFECTION; EPIDEMIOLOGY; PREVALENCE; CHILDREN; URBAN;

D O I：

10.1016/j.vaccine.2010.02.101

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A population-based sero-epidemiological study enrolled 9486 volunteers in two governorates, Beja in the north and Tataouine in the south of Tunisia, in order to assess the magnitude of HBV transmission heterogeneity between the north and the south and within the same governorate. as well as the risk factors associated with infection and chronic carriage. Results The overall prevalence of anti-HBc, HBsAg and chronic carriage was 28 5.5 3 and 2 9%, respectively Significant differences were observed between the two governorates according to anti-HBc (32.1% in Beja and 27.8% in Tataouine, p = 0 005) and HBsAg prevalence (42% in Beja and 5.6% in Tataouine: p = 0001). Significant differences were noticed between districts revealing important heterogeneity in HBV transmission within the same governorate (HBsAg ranged from 12 to <2% within the same governorate). At the individual level, the presence of a family member infected with HBV, scarification practices, needle practices in the Primary Care Center and gender (male) significantly increased the risk of anti-Hbc, HBsAg positivity and chronic carriage of infection while existence of sanitation in the house was found to be protective The basic reproductive number and the force of infection confirmed the heterogeneity of transmission Horizontal transmission within the family explains hyperendemic clusters in Tunisia (C) 2010 Elsevier Ltd All rights reserved

引用

页码：3301 / 3307

页数：7