Synovium-Derived Mesenchymal Stem Cell Transplantation in Cartilage Regeneration: A PRISMA Review of in vivo Studies

被引:45
|
作者
To, Kendrick [1 ]
Zhang, Bridget [2 ]
Romain, Karl [2 ]
Mak, Christopher [2 ]
Khan, Wasim [1 ]
机构
[1] Univ Cambridge, Dept Surg, Div Trauma & Orthopaed, Addenbrookes Hosp, Cambridge, England
[2] Univ Cambridge, Sch Clin Med, Cambridge, England
来源
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2019年 / 7卷
关键词
mesenchymal stem cells; synovium; transplantation; cartilage repair; osteoarthritis; REPAIR OSTEOCHONDRAL DEFECTS; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; INTRAARTICULAR INJECTION; UMBILICAL-CORD; STROMAL CELLS; KNEE; OSTEOARTHRITIS; VITRO; EPIDEMIOLOGY;
D O I
10.3389/fbioe.2019.00314
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Articular cartilage damaged through trauma or disease has a limited ability to repair. Untreated, focal lesions progress to generalized changes including osteoarthritis. Musculoskeletal disorders including osteoarthritis are the most significant contributor to disability globally. There is increasing interest in the use of mesenchymal stem cells (MSCs) for the treatment of focal chondral lesions. There is some evidence to suggest that the tissue type from which MSCs are harvested play a role in determining their ability to regenerate cartilage in vitro and in vivo. In humans, MSCs derived from synovial tissue may have superior chondrogenic potential. We carried out a systematic literature review on the effectiveness of synovium-derived MSCs (sMSCs) in cartilage regeneration in in vivo studies in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Twenty studies were included in our review; four examined the use of human sMSCs and 16 were conducted using sMSCs harvested from animals. Most studies reported successful cartilage repair with sMSC transplantation despite the variability of animals, cell harvesting techniques, methods of delivery, and outcome measures. We conclude that sMSC transplantation holds promise as a treatment option for focal cartilage defects. We believe that defining the cell population being used, establishing standardized methods for MSC delivery, and the use of objective outcome measures should enable future high quality studies such as randomized controlled clinical trials to provide the evidence needed to manage chondral lesions optimally.
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页数:14
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