Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface

被引：28

作者：

Novozhilova, N. M. ^{[1
]}

Bovin, N. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2010年 / 75卷 / 06期

关键词：

D-arabinopyranose; Leishmania; glycosylphosphatidylinositol; lipophosphoglycan; glycosylinositol phospholipids; proteophosphoglycan; PROTEIN-KINASE-C; PROTOZOAN PARASITE LEISHMANIA; TARGETED GENE DELETION; NITRIC-OXIDE SYNTHASE; GLYCOSYLATED-PHOSPHATIDYLINOSITOLS; MEXICANA AMASTIGOTES; SIGNAL-TRANSDUCTION; TRYPANOSOMA-BRUCEI; D-ARABINOPYRANOSE; LIPOPHOSPHOGLYCAN;

D O I：

10.1134/S0006297910060027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishmania cell surface, many of which incorporate the rare natural D-arabinopyranose, and the problem concerning the involvement of these molecules in support of Leishmania survival during their intricate life cycle is discussed.

引用

页码：686 / 694

页数：9

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