Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface

被引：28
作者：
Novozhilova, N. M. [1 ]
Bovin, N. V. [1 ]
机构：
[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2010年 / 75卷 / 06期
关键词：
D-arabinopyranose; Leishmania; glycosylphosphatidylinositol; lipophosphoglycan; glycosylinositol phospholipids; proteophosphoglycan; PROTEIN-KINASE-C; PROTOZOAN PARASITE LEISHMANIA; TARGETED GENE DELETION; NITRIC-OXIDE SYNTHASE; GLYCOSYLATED-PHOSPHATIDYLINOSITOLS; MEXICANA AMASTIGOTES; SIGNAL-TRANSDUCTION; TRYPANOSOMA-BRUCEI; D-ARABINOPYRANOSE; LIPOPHOSPHOGLYCAN;
D O I：
10.1134/S0006297910060027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishmania cell surface, many of which incorporate the rare natural D-arabinopyranose, and the problem concerning the involvement of these molecules in support of Leishmania survival during their intricate life cycle is discussed.
引用
收藏
页码：686 / 694
页数：9
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