MicroRNA-Regulated Protein-Protein Interaction Networks: How Could They Help in Searching for Pro-Longevity Targets?

被引:23
作者
Tacutu, Robi [1 ]
Budovsky, Arie [1 ]
Wolfson, Marina [1 ]
Fraifeld, Vadim E. [1 ]
机构
[1] Ben Gurion Univ Negev, Fac Hlth Sci, Shraga Segal Dept Microbiol & Immunol, Ctr Multidisciplinary Res Aging, IL-84105 Beer Sheva, Israel
关键词
DISEASE; GENES; EPIGENETICS; DATABASE; SYSTEMS;
D O I
10.1089/rej.2009.0980
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging and age-related diseases (ARDs), and ultimately to promote longevity, are still very modest. What is lacking-essential data on key players, efficient analytic tools, or both? Here we discuss how the existing data may be integrated and analyzed in the context of microRNA (miRNA)-regulated protein-protein interaction networks. The proposed model highlighted: (1) The strong molecular links between aging, longevity, and ARDs; (2) the possibility and even the preferability of initiating longevity-promoting interventions in adult life; (3) the potentially important role for miRNA- (or small interfering RNA [siRNA]) mediated targeting of certain genes with features of antagonistic pleiotropy; (4) the superiority of systemic interventions to the common single-target approach in curing ARDs and promoting longevity.
引用
收藏
页码:373 / 377
页数:5
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