3-Acetylcoumarin as a Practical Ligand for Copper-Catalyzed C-N Coupling Reactions at Room Temperature

被引：21

作者：

Tao, Chuan-Zhou ^{[1
,2
]}

Liu, Wei-Wei ^{[1
]}

Sun, Ji-You ^{[1
]}

Cao, Zhi-Ling ^{[1
]}

Li, Hui ^{[1
]}

Zhang, Ying-Fen ^{[1
]}

机构：

[1] Huaihai Inst Technol, Dept Chem Engn, Lianyungang 222005, Peoples R China

[2] Huaihai Inst Technol, Jiangsu Key Lab Marine Biotechnol, Lianyungang 222005, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2010年 / 08期

关键词：

copper; catalysis; cross-coupling; 3-acetylcoumarin; room temperature; LONG-LIVED CATALYSTS; ARYL IODIDES; BOND FORMATION; CONTAINING HETEROCYCLES; NITROGEN NUCLEOPHILES; HETEROARYL HALIDES; GOLDBERG REACTIONS; AMINATION; ARYLATION; EFFICIENT;

D O I：

10.1055/s-0029-1218661

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of coumarin-based ligands was examined in copper-catalyzed C-N cross-coupling reactions. It was found that 3-acetylcoumarin constituted a new, practical ligand for the copper-catalyzed N-arylation of aliphatic amines and imidazole with aryl iodides at room temperature. Aryl bromides could also be aminated efficiently at 80 degrees C. This readily available catalyst system, namely copper(I) iodide and 3-acetylcoumarin, provides a mild and practical method for the synthesis of aromatic amines.

引用

页码：1280 / 1284

页数：5

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