Anticancer activity of a ceramide analog containing a disulfide linkage

被引：17
作者：
Bittman, Robert
Li, Zaiguo
Samadder, Pranati
Arthur, Gilbert [1 ]
机构：
[1] CUNY Queens Coll, Dept Chem & Biochem, Flushing, NY 11367 USA
[2] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada
来源：
CANCER LETTERS | 2007年 / 251卷 / 01期
关键词：
ceramide; synthesis; antiproliferation; cytotoxic; glutathione;
D O I：
10.1016/j.canlet.2006.10.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effects of exogenous short-chain ceramide (1) on the arrest of growth of cancer cells in vitro and induction of apoptosis have been well documented. In the present study, an analog of 1 with a disulfide linkage, N-(4',5'-dithiaheptanoyl)-D-erythro-ceramide (2), was synthesized and found to be significantly more antiproliferative and cytotoxic than 1 in BT549, A549, and DU145 cancer cells. The activity was correlated with a reduction in cellular glutathione (GSH) level. Ceramide analogs with a tri- and tetra-sulfide moiety were also prepared, but they did not deplete cellular GSH levels and did not possess antiproliferative or cytotoxic properties. (c) 2007 Published by Elsevier Ireland Ltd.
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收藏
页码：53 / 58
页数：6
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