The colony-stimulating factors and cancer

被引：124

作者：

Metcalf, Donald ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

BLOOD PROGENITOR CELLS; BONE-MARROW-CELLS; AUGMENTS ANTITUMOR IMMUNITY; AUTOLOGOUS TUMOR VACCINES; IN-VITRO CONTROL; MULTI-CSF IL-3; HUMAN GM-CSF; GROWTH-FACTOR; HEMATOPOIETIC-CELLS; MOLECULAR-CLONING;

D O I：

10.1038/nrc2843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.

引用

页码：425 / 434

页数：10

共 159 条

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