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PATTERN OF MATRIX METALLOPROTEINASES-9, P53 AND BCL-2 PROTEINS IN EGYPTIAN PATIENTS WITH PULMONARY MYCOBACTERIUM TUBERCULOSIS
被引:6
作者:
El-Masry, Samir
[1
]
Lotfy, Mahmoud
[1
]
Samy, Mona
[2
]
Moawia, Shadin
[1
]
El-Sayed, Ibrahim H.
[1
]
Khamees, Islam M.
[1
]
机构:
[1] Menoufia Univ, Genet Engn & Biotechnol Res Inst, Dept Mol & Cellular Biol, Sadat City, Minufiya, Egypt
[2] Mansoura Univ, Children Hosp, Mansoura, Egypt
关键词:
Mycobacterium tuberculosis;
matrix metalloproteinases;
P53;
Bcl-2;
HUMAN MONOCYTIC CELLS;
GELATINOLYTIC ACTIVITY;
TISSUE INHIBITOR;
APOPTOSIS;
MACROPHAGES;
HOST;
EXPRESSION;
INDUCTION;
RELEASE;
MATRIX-METALLOPROTEINASE-9;
D O I:
10.1556/AMicr.57.2010.2.5
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Matrix metalloproteinases (MMPs) constitute a large family of enzymes that degrade extracellular matrix proteins (ECM). MMPs are implicated in different pathological conditions such as cancer. Bcl-2 and P53 are key controllers of programmed cell death (PCD) or apoptosis. The aim of the present study was to determine the MMP-9, P53 and Bcl-2 levels in Egyptian patients with Mycobacterium tuberculosis (MTB) (Group I) compared with healthy control individuals (Group II). The concentrations of serum MMP-9 were determined quantitatively using enzyme immunoassay (EIA). P53 and Bcl-2 levels were assayed by flow cytometric analysis using specific monoclones. MMP-9 level was significantly higher in MTB patients compared with healthy control. Similarly, P53 and Bcl-2 levels were increased in MTB patients compared with healthy ones. These data reflect the alteration of MMP-9 level during the course of MTB infection, accompanied with apparent dysregulation of cellular apoptosis as indicated by P53 and Bcl-2 over-expression.
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页码:123 / 133
页数:11
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