Issues and progress with protein kinase inhibitors for cancer treatment

被引：425

作者：

Dancey, J

Sausville, EA

机构：

[1] NCI, Div Canc Treatment & Diag, Canc Therapy Evaluat Program, Investigat Drug Branch, Rockville, MD 20852 USA

[2] NCI, Div Canc Treatment & Diag, Dev Therapeut Program, Rockville, MD 20852 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 04期

关键词：

D O I：

10.1038/nrd1066

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Identification of the key roles of protein kinases in cancer has led to extensive efforts to develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 such agents are now in clinical trials. Here, we consider the crucial issues in the development of kinase inhibitors for cancer, and discuss strategies to address the challenges raised by these issues in the light of preclinical and clinical experiences so far.

引用

页码：296 / 313

页数：18

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