Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway

被引：19

作者：

Xia, Erjie ^{[1
]}

Zhou, Xiaofen ^{[1
]}

Bhandari, Adheesh ^{[1
]}

Zhang, Xiaohua ^{[1
]}

Wang, Ouchen ^{[1
]}

机构：

[1] Wenzhou Med Univ, Dept Thyroid & Breast Surg, Affiliated Hosp 1, Nanbai Xiang St, Wenzhou 325000, Zhejiang, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2018年 / 10卷

关键词：

breast cancer; SYNPO2; metastasis; PI3K/AKT/mTOR signaling pathway; GENE-EXPRESSION; INVASION; SYNPO2;

D O I：

10.2147/CMAR.S162670

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Synaptopodin 2 (SYNPO2) is a functioning protein. It has been detected in many malignancies. But the relation between SYNPO2 and breast cancer (BC) is unclear. Materials and methods: In this study, we explored the expression and function of SYNPO2 in BC. We found that SYNPO2 gene in BC was downregulated at the transcriptional level in both validated and TCGA cohorts. Results: The results revealed that age, lymph node metastasis, and clinical stage in the validated cohort were related to the expression of SYNPO2 negatively. Kaplan-Meier analysis showed that patients with lower SYNPO2 expression had a worse overall survival. Discussion: We found that migration and invasion were promoted after knocking down SYNPO2 in MCF-7, MDA-MB-231, BT-549, and MDA-MB-468. Meanwhile, knockdown of SYNPO2 could enhance PI3K/AKT/mTOR signaling pathway, which may induce migration and invasion. Our findings reveal that SYNPO2 was associated with BC.

引用

收藏

页码：1575 / 1583

页数：9

相关论文

共 19 条

[1] Role of the chemokine receptor CXCR4 in breast cancer metastasis [J].

Ahmed, M. I. ;

Harvey, J. R. ;

Kirby, J. ;

Ali, S. ;

Lennard, T. W. J. .

EJC SUPPLEMENTS, 2007, 5 (03) :30-30

[2] Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells [J].

De Ganck, Ariane ;

De Corte, Veerle ;

Bruyneel, Erik ;

Bracke, Marc ;

Vandekerckhove, Joel ;

Gettemans, Jan .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (05) :1403-1409

[3] The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism [J].

Engelman, Jeffrey A. ;

Luo, Ji ;

Cantley, Lewis C. .

NATURE REVIEWS GENETICS, 2006, 7 (08) :606-619

[4] Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma [J].

Gao, Linda ;

van den Hurk, Karin ;

Nsengimana, Jeremie ;

Laye, Jonathan P. ;

van den Oord, Joost J. ;

Beck, Samuel ;

Gruis, Nelleke A. ;

Zoutman, Willem H. ;

van Engeland, Manon ;

Newton-Bishop, Julia A. ;

Winnepenninckx, Veronique J. ;

van Doorn, Remco .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (09) :2328-2331

[5] MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer [J].

Hu, Guohong ;

Chong, Robert A. ;

Yang, Qifeng ;

Wei, Yong ;

Blanco, Mario A. ;

Li, Feng ;

Reiss, Michael ;

Au, Jessie L. -S. ;

Haffty, Bruce G. ;

Kang, Yibin .

CANCER CELL, 2009, 15 (01) :9-20

[6] Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models [J].

Issa, Amine ;

Gill, Jason W. ;

Heideman, Marinus R. ;

Sahin, Ozgur ;

Wiemann, Stefan ;

Dey, Julien H. ;

Hynes, Nancy E. .

BREAST CANCER RESEARCH, 2013, 15 (01)

[7] Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration [J].

Kai, FuiBoon ;

Fawcett, James P. ;

Duncan, Roy .

ONCOTARGET, 2015, 6 (13) :11162-11174

[8] Prostate cancer cell migration induced by myopodin isoforms is associated with formation of morphologically and biochemically distinct actin networks [J].

Kai, FuiBoon ;

Duncan, Roy .

FASEB JOURNAL, 2013, 27 (12) :5046-5058

[9] MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway [J].

Ke, Kongliang ;

Lou, Tingting .

ONCOLOGY LETTERS, 2017, 14 (05) :5994-6000

[10] Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity [J].

Liu, Junling ;

Ye, Liping ;

Li, Qingyuan ;

Wu, Xianqiu ;

Wang, Bin ;

Ouyang, Ying ;

Yuan, Zhongyu ;

Li, Jun ;

Lin, Chuyong .

JOURNAL OF PATHOLOGY, 2018, 244 (01) :71-83