A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

被引：147

作者：

Ebenezer, Oluwakemi ^{[1
,2
]}

Shapi, Michael ^{[1
]}

Tuszynski, Jack A. ^{[2
,3
,4
]}

机构：

[1] Mangosuthu Univ Technol, Fac Nat Sci, Dept Chem, ZA-4026 Durban, South Africa

[2] Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada

[3] Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

[4] Politecn Torino, Dept Mech & Aerosp Engn, DIMEAS, I-10129 Turin, Italy

来源：

BIOMEDICINES | 2022年 / 10卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

heterocycle; pyrazole; derivatives; synthesis; biological activities; recent development; ONE-POT SYNTHESIS; MOLECULAR DOCKING; ANTICANCER ACTIVITY; DESIGN; INHIBITORS; DISCOVERY; CYTOTOXICITY; CASCADE; BEARING; IDENTIFICATION;

D O I：

10.3390/biomedicines10051124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an important class of compounds for drug development; thus, they have attracted much attention. In the meantime, pyrazole derivatives have been synthesized as target structures and have demonstrated numerous biological activities such as antituberculosis, antimicrobial, antifungal, and anti-inflammatory. This review summarizes the results of published research on pyrazole derivatives synthesis and biological activities. The published research works on pyrazole derivatives synthesis and biological activities between January 2018 and December 2021 were retrieved from the Scopus database and reviewed accordingly.

引用

页数：57

共 157 条

[31] Discovery of 1,3,4,5-tetrasubstituted pyrazoles as anti-trypanosomatid agents: Identification of alterations in flagellar structure of L. amazonensis [J].

da Silva, Michael J., V ;

Jacomini, Andrey P. ;

Goncalves, Davana S. ;

Pianoski, Karlos Eduardo ;

Poletto, Julia ;

Lazarin-Bidoia, Danielle ;

Volpato, Helito ;

Nakamura, Celso, V ;

Rosa, Fernanda A. .

BIOORGANIC CHEMISTRY, 2021, 114

[32] Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase [J].

Dawood, Dina H. ;

Nossier, Eman S. ;

Ali, Mamdouh M. ;

Mahmoud, Abeer E. .

BIOORGANIC CHEMISTRY, 2020, 101

[33] Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles [J].

de Oliveira, Daniela Hartwig ;

Sabedra Sousa, Fernanda Severo ;

Birmann, Paloma Taborda ;

Pesarico, Ana Paula ;

Alves, Diego ;

Jacob, Raquel Guimaraes ;

Savegnago, Lucielli .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2020, 98 (07) :441-448

[34] Conventional and Microwave-Assisted Synthesis, Antitubercular Activity, and Molecular Docking Studies of Pyrazole and Oxadiazole Hybrids [J].

Desai, Nisheeth C. ;

Bhatt, Kandarp ;

Monapara, Jahnvi ;

Pandit, Unnat ;

Khedkar, Vijay M. .

ACS OMEGA, 2021, 6 (42) :28270-28284

[35] Synthesis, biological evaluation, and molecular docking studies of novel pyrazole, pyrazoline-clubbed pyridine as potential antimicrobial agents [J].

Desai, Nisheeth C. ;

Vaja, Darshita V. ;

Monapara, Jahnvi D. ;

Manga, Vijjulatha ;

Vani, Tamalapakula .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 58 (03) :737-750

[36] Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements [J].

Dimirjian, Christine A. ;

Reis, Marta Castineira ;

Balmond, Edward I. ;

Turman, Nolan C. ;

Rodriguez, Elys P. ;

Di Maso, Michael J. ;

Fettinger, James C. ;

Tantillo, Dean J. ;

Shaw, Jared T. .

ORGANIC LETTERS, 2019, 21 (18) :7209-7212

[37] Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity [J].

Dimmito, Marilisa P. ;

Stefanucci, Azzurra ;

Pieretti, Stefano ;

Minosi, Paola ;

Dvoracsko, Szabolcs ;

Tomboly, Csaba ;

Zengin, Gokhan ;

Mollica, Adriano .

BIOMOLECULES, 2019, 9 (09)

[38] Synthesis of pyrazole-4-carboxamides as potential fungicide candidates [J].

Dong, Cuntao ;

Gao, Wei ;

Li, Xiaotian ;

Sun, Susu ;

Huo, Jingqian ;

Wang, Yanen ;

Ren, Da ;

Zhang, Jinlin ;

Chen, Lai .

MOLECULAR DIVERSITY, 2021, 25 (04) :2379-2388

[39] Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzy1-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine [J].

Dvorak, Curt A. ;

Liang, Jimmy ;

Mani, Neelakandha S. ;

Carruthers, Nicholas, I .

TETRAHEDRON LETTERS, 2021, 67

[40] Antibacterial evaluation and molecular docking studies of pyrazole-thiosemicarbazones and their pyrazole-thiazolidinone conjugates [J].

Ebenezer, Oluwakemi ;

Singh-Pillay, Ashona ;

Koorbanally, Neil A. ;

Singh, Parvesh .

MOLECULAR DIVERSITY, 2021, 25 (01) :191-204

← 1 2 3 4 5 6 7 8 9 10 →