Diagnosis of invasive pulmonary aspergillosis: Value of bronchoalveolar lavage galactomannan for immunocompromised patients

被引：9

作者：

Paugam, A. ^{[1
]}

Baixench, M. -T. ^{[1
]}

Lebuisson, A. ^{[1
]}

Dupouy-Camet, J. ^{[1
]}

机构：

[1] Univ Paris 05, AP HP, Hop Cochin, Lab Parasitol Mycol, F-75014 Paris, France

来源：

PATHOLOGIE BIOLOGIE | 2010年 / 58卷 / 01期

关键词：

Galactomannan; Bronchoalveolar lavage; Invasive pulmonary aspergillosis; Immunosuppression; LINKED-IMMUNOSORBENT-ASSAY; ENZYME-IMMUNOASSAY; TRANSPLANT RECIPIENTS; CIRCULATING GALACTOMANNAN; HEMATOLOGICAL PATIENTS; FLUID; ANTIGEN; MANAGEMENT; RISK; EPIDEMIOLOGY;

D O I：

10.1016/j.patbio.2009.07.011

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Invasive pulmonary aspergillosis (IPA) is an emerging disease associated with high mortality. The diagnosis is difficult, based on a combination ofelements that are clinical, radiological and biological. For early detection of cases of IPA, during 25 months,we have systematically carried out on the LBA(N = 355) of immunocompromised patients (N = 313) a determination of Aspergillus galactomannan (GM) by ELISA (Platelia (R) Aspergillus, BioRad). We observed 14 cases of probable API. The sensitivity of GM compared to direct examination (DE) and culture is, respectively, 64% versus 29% and 57%. The determination of GM is definitely more sensitive than the ED. Excellent specificity (98%) allows its implementation as a screening test in patients at risk. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：100 / 103

页数：4

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