Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney

被引：12
|
作者：
Torres, AM
MacLaughlin, M
Quaglia, NB
Stremmel, W
机构：
[1] UNR, CONICET, Fac Ciencias Bioquim & Farmaceut, Rosario, Santa Fe, Argentina
[2] UBA, CONICET, Fac Med, Inst Invest Cardiol, Buenos Aires, DF, Argentina
[3] Univ Heidelberg, Med Klin, D-6900 Heidelberg, Germany
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2003年 / 245卷 / 1-2期
关键词：
BSP/Bilirubin binding protein; p-aminohippuric acid; brush border membrane vesicles; basolateral membrane vesicles; renal tubular secretion;
D O I：
10.1023/A:1022833713727
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
BSP/Bilirubin binding protein (BBBP) is a protein located on the sinusoidal membrane of the liver that transport several organic anions. The aim of this investigation was to determine whether BBBP is present in the kidney and its role in p-aminohippurate transport (PAH). Anti-BBBP antibodies inhibited PAH uptake in brush border membrane vesicles (BBMV) and Na+-independent PAH uptake in basolateral membrane vesicles (BLMV). Western blot studies revealed positivity to antiBBBP antibodies in both BBMV and BLMV. So BBBP is also expressed in the kidneys and accounts, at least in part, for the renal tubular transport of PAH.
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页码：149 / 156
页数：8
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