Structure of HIV-1 nonnucleoside reverse transcriptase inhibitors derivatives of N-benzyl-benzimidazole with different substituents in position 4

被引：5

作者：

Ziolkowska, Natasza E. ^{[1
]}

Michejda, Christopher J. ^{[2
]}

Bujacz, Grzegorz D. ^{[1
]}

机构：

[1] Tech Univ Lodz, Inst Tech Biochem, PL-90924 Lodz, Poland

[2] NCI, Mol Aspects Drug Design Sect, Frederick, MD 21702 USA

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2010年 / 963卷 / 2-3期

关键词：

AIDS; HIV-1; Reverse transcriptase inhibitor; Drug design; Crystal structure; HUMAN-IMMUNODEFICIENCY-VIRUS; BIOLOGICAL-ACTIVITY; POTENT; BINDING; 1H,3H-THIAZOLO<3,4-A>BENZIMIDAZOLES; REPLICATION; DELAVIRDINE; MUTATIONS; INFECTION; COMPLEX;

D O I：

10.1016/j.molstruc.2009.10.034

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The constant development of new drugs against HIV-1 is necessary due to global expansion of AIDS and HIV-1 drug resistance. Nonnucleoside reverse transcriptase inhibitors of HIV-1 (NNRTIs) are potentially effective and nontoxic drugs in AIDS therapy. The crystal structures of six nonnucleoside inhibitors of HIV-1 reverse transcriptase (RT) derivatives of N-benzyl-benzimidazole are reported here. The investigated compounds belong to the group of so called "butterfly like" inhibitors with characteristic two pi-electron moieties with an angled orientation. The structural data show the influence of the substituents of the benzimidazole ring on the geometry of the molecule and correlation between the structure of the inhibitor and its biological activity. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：188 / 193

页数：6

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