High activity of K+-dependent plasmalemmal Na+/Ca2+ exchangers in hippocampal CAI neurons

被引：28

作者：

Kiedrowski, L

机构：

[1] Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA

[2] Univ Illinois, Inst Psychiat, Dept Pharmacol, Chicago, IL 60612 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 13期

关键词：

CAI neurons; calcium; cerebellar granule cells; forebrain neurons; hippocampus; ischemia; NCX; NCKX; sodium;

D O I：

10.1097/00001756-200409150-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca2+ influx via reversed K+-dependent (NCKX) and/or K+-independent (NCX) plasmalernmal Na+/Ca2+ exchangers may play a role in neuronal death following global brain ischemia to which CAI neurons are particularly vulnerable. Therefore, this work tested whether the rates of Ca2+ influx via reversed NCKX or NCX in cultured rat CAI neurons differ from those in forebrain neurons (FNs) or cerebellar granule cells (CGCs). The NCKX-mediated Ca2+ influx was several times more rapid in CAI neurons than in FNs or CGCs and was not affected by Na+/ Ca2+ exchange inhibitors, KB-R7943 or bepridil. NCKX reversal inhibitors are not yet available. Their development would greatly facilitate further testing the role of NCKX in ischemic death of CAI neurons.

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页码：2113 / 2116

页数：4

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