共 32 条
Why do essential proteins tend to be clustered in the yeast interactome network?
被引:15
作者:

Lu, Chenqi
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Hu, Xiaohua
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Wang, Guiying
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China
Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Leach, L. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Yang, Shengjie
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Kearsey, M. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China

Luo, Z. W.
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China
Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China
机构:
[1] Fudan Univ, Lab Populat & Quantitat Genet, Inst Biostat, SKLGE,Sch Life Sci, Shanghai 200433, Peoples R China
[2] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
[3] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
基金:
英国生物技术与生命科学研究理事会;
关键词:
SACCHAROMYCES-CEREVISIAE;
COMPLEXES;
MODULARITY;
CENTRALITY;
LETHALITY;
MAP;
D O I:
10.1039/b921069e
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Recently, the debate on the centrality-lethality rule is resolved by the "second-generation" high-throughput Y2H data from the yeast interactome network, which suggests no significant correlation between the degree of connectedness and essentiality of proteins. However, it is still not clear why essential proteins strongly tend to interact with each other. Previously, the concept of essential protein-protein interactions was proposed to explain the mechanism underlying the clustering of essential proteins. In this article we show that 67 to 75% of the excessive interactions between essential proteins (IBEPs) in the yeast interactome network can be attributed to interactions within protein complexes characterised by the same deletion phenotype for subunits within the complex. Furthermore, 20 to 78% of the excess in IBEPs are caused by the strongly modular structure of the network and by variation in protein essentiality among modules. Not only do proteins function as an interactive network in cellular processes, but furthermore, many proteins do not take part in the network alone, but integrate into protein complexes and many functionally related complexes integrate into modules. So, the local structure of protein complexes as both functional and structural modules are the main contributory factors in the clustering of essential proteins.
引用
收藏
页码:871 / 877
页数:7
相关论文
共 32 条
[1]
Analyzing yeast protein-protein interaction data obtained from different sources
[J].
Bader, GD
;
Hogue, CWV
.
NATURE BIOTECHNOLOGY,
2002, 20 (10)
:991-997

Bader, GD
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

Hogue, CWV
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2]
Evolutionary and physiological importance of hub proteins
[J].
Batada, Nizar N.
;
Hurst, Laurence D.
;
Tyers, Mike
.
PLOS COMPUTATIONAL BIOLOGY,
2006, 2 (07)
:748-756

Batada, Nizar N.
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

Hurst, Laurence D.
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

Tyers, Mike
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[3]
Protein domain connectivity and essentiality
[J].
Costa, L. da F.
;
Rodrigues, F. A.
;
Travieso, G.
.
APPLIED PHYSICS LETTERS,
2006, 89 (17)

Costa, L. da F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil

Rodrigues, F. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil

Travieso, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[4]
Comparing community structure identification -: art. no. P09008
[J].
Danon, L
;
Díaz-Guilera, A
;
Duch, J
;
Arenas, A
.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT,
2005,
:219-228

Danon, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Barcelona, Dept Fis Fonamental, Barcelona 08086, Spain

Díaz-Guilera, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Barcelona, Dept Fis Fonamental, Barcelona 08086, Spain

Duch, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Barcelona, Dept Fis Fonamental, Barcelona 08086, Spain

Arenas, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Barcelona, Dept Fis Fonamental, Barcelona 08086, Spain
[5]
Bioinformatics analysis of experimentally determined protein complexes in the yeast Saccharomyces cerevisiae
[J].
Dezso, Z
;
Oltvai, ZN
;
Barabási, AL
.
GENOME RESEARCH,
2003, 13 (11)
:2450-2454

Dezso, Z
论文数: 0 引用数: 0
h-index: 0
机构: Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA

Oltvai, ZN
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA

Barabási, AL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA
[6]
Functional organization of the yeast proteome by systematic analysis of protein complexes
[J].
Gavin, AC
;
Bösche, M
;
Krause, R
;
Grandi, P
;
Marzioch, M
;
Bauer, A
;
Schultz, J
;
Rick, JM
;
Michon, AM
;
Cruciat, CM
;
Remor, M
;
Höfert, C
;
Schelder, M
;
Brajenovic, M
;
Ruffner, H
;
Merino, A
;
Klein, K
;
Hudak, M
;
Dickson, D
;
Rudi, T
;
Gnau, V
;
Bauch, A
;
Bastuck, S
;
Huhse, B
;
Leutwein, C
;
Heurtier, MA
;
Copley, RR
;
Edelmann, A
;
Querfurth, E
;
Rybin, V
;
Drewes, G
;
Raida, M
;
Bouwmeester, T
;
Bork, P
;
Seraphin, B
;
Kuster, B
;
Neubauer, G
;
Superti-Furga, G
.
NATURE,
2002, 415 (6868)
:141-147

Gavin, AC
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bösche, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Krause, R
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Grandi, P
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Marzioch, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bauer, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Schultz, J
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rick, JM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Michon, AM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Cruciat, CM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Remor, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Höfert, C
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Schelder, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Brajenovic, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Ruffner, H
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Merino, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Klein, K
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Hudak, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Dickson, D
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rudi, T
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Gnau, V
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bauch, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bastuck, S
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Huhse, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Leutwein, C
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Heurtier, MA
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Copley, RR
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Edelmann, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Querfurth, E
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rybin, V
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Drewes, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Raida, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bouwmeester, T
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bork, P
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Seraphin, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Kuster, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Neubauer, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Superti-Furga, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany
[7]
Functional profiling of the Saccharomyces cerevisiae genome
[J].
Giaever, G
;
Chu, AM
;
Ni, L
;
Connelly, C
;
Riles, L
;
Véronneau, S
;
Dow, S
;
Lucau-Danila, A
;
Anderson, K
;
André, B
;
Arkin, AP
;
Astromoff, A
;
El Bakkoury, M
;
Bangham, R
;
Benito, R
;
Brachat, S
;
Campanaro, S
;
Curtiss, M
;
Davis, K
;
Deutschbauer, A
;
Entian, KD
;
Flaherty, P
;
Foury, F
;
Garfinkel, DJ
;
Gerstein, M
;
Gotte, D
;
Güldener, U
;
Hegemann, JH
;
Hempel, S
;
Herman, Z
;
Jaramillo, DF
;
Kelly, DE
;
Kelly, SL
;
Kötter, P
;
LaBonte, D
;
Lamb, DC
;
Lan, N
;
Liang, H
;
Liao, H
;
Liu, L
;
Luo, CY
;
Lussier, M
;
Mao, R
;
Menard, P
;
Ooi, SL
;
Revuelta, JL
;
Roberts, CJ
;
Rose, M
;
Ross-Macdonald, P
;
Scherens, B
.
NATURE,
2002, 418 (6896)
:387-391

Giaever, G
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Chu, AM
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Ni, L
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Connelly, C
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Riles, L
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Véronneau, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Dow, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Lucau-Danila, A
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Anderson, K
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

André, B
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Arkin, AP
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Astromoff, A
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

El Bakkoury, M
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Bangham, R
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Benito, R
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Brachat, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Campanaro, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Curtiss, M
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Davis, K
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Deutschbauer, A
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Entian, KD
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Flaherty, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Foury, F
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Garfinkel, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Gerstein, M
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Gotte, D
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Güldener, U
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Hegemann, JH
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Hempel, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Herman, Z
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Jaramillo, DF
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Kelly, DE
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Kelly, SL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Kötter, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

LaBonte, D
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Lamb, DC
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Lan, N
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Liang, H
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Liao, H
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Liu, L
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Luo, CY
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Lussier, M
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Mao, R
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Menard, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Ooi, SL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Revuelta, JL
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Roberts, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Rose, M
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Ross-Macdonald, P
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

Scherens, B
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA
[8]
Functional cartography of complex metabolic networks
[J].
Guimerà, R
;
Amaral, LAN
.
NATURE,
2005, 433 (7028)
:895-900

Guimerà, R
论文数: 0 引用数: 0
h-index: 0
机构: Northwestern Univ, NICO, Evanston, IL 60208 USA

Amaral, LAN
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, NICO, Evanston, IL 60208 USA Northwestern Univ, NICO, Evanston, IL 60208 USA
[9]
Molecular evolution in large genetic networks: Does connectivity equal constraint?
[J].
Hahn, MW
;
Conant, GC
;
Wagner, A
.
JOURNAL OF MOLECULAR EVOLUTION,
2004, 58 (02)
:203-211

Hahn, MW
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Dept Biol, Durham, NC 27708 USA

Conant, GC
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Dept Biol, Durham, NC 27708 USA

Wagner, A
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Dept Biol, Durham, NC 27708 USA
[10]
Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks
[J].
Hahn, MW
;
Kern, AD
.
MOLECULAR BIOLOGY AND EVOLUTION,
2005, 22 (04)
:803-806

Hahn, MW
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

Kern, AD
论文数: 0 引用数: 0
h-index: 0
机构: Indiana Univ, Dept Biol, Bloomington, IN 47405 USA