Coronary Calcium Score and Cardiovascular Risk

被引：667

作者：

Greenland, Philip ^{[1
,2
]}

Blaha, Michael J. ^{[3
]}

Budoff, Matthew J. ^{[4
]}

Erbel, Raimund ^{[5
]}

Watson, Karol E. ^{[6
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 North Lake Shore Dr,Suite 1400, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[3] Johns Hopkins Sch Med, Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA

[4] LA BioMed, Dept Med, Torrance, CA USA

[5] Univ Clin, Inst Med Informat Biometry & Epidemiol, Essen, Germany

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2018年 / 72卷 / 04期

基金：

美国国家卫生研究院;

关键词：

aspirin; atherosclerotic cardiovascular disease; coronary artery calcification; coronary heart disease; statins; BEAM COMPUTED-TOMOGRAPHY; HEINZ NIXDORF RECALL; CHOLESTEROL MANAGEMENT GUIDELINES; EISNER EARLY IDENTIFICATION; HEART-DISEASE EVENTS; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN; ARTERY CALCIUM; COST-EFFECTIVENESS; STATIN THERAPY;

D O I：

10.1016/j.jacc.2018.05.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year followup), CAC scoring has emerged as a widely available, consistent, and reproducible means of assessing risk for major cardiovascular outcomes, especially useful in asymptomatic people for planning primary prevention interventions such as statins and aspirin. CAC testing in asymptomatic populations is cost effective across a broad range of baseline risk. This review summarizes evidence concerning CAC, including its pathobiology, modalities for detection, predictive role, use in prediction scoring algorithms, CAC progression, evidence that CAC changes the clinical approach to the patient and patient behavior, novel applications of CAC, future directions in scoring CAC scans, and new CAC guidelines. (C) 2018 by the American College of Cardiology Foundation.

引用

页码：434 / 447

页数：14

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