Role of extracellular vesicles in neurodegenerative diseases

被引：50

作者：

Xiao, Yun ^{[1
]}

Wang, Shu-Kun ^{[2
]}

Zhang, Yuan ^{[1
]}

Rostami, Abdolmohamad ^{[3
]}

Kenkare, Anshel ^{[3
]}

Casella, Giacomo ^{[3
]}

Yuan, Zeng-Qiang ^{[2
]}

Li, Xing ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Natl Engn Lab Resource Dev Endangered Crude Drugs, Minist Educ Med Resources & Nat Pharmaceut Chem, Key Lab,Coll Life Sci, Xian 710119, Shaanxi, Peoples R China

[2] Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China

[3] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA

来源：

PROGRESS IN NEUROBIOLOGY | 2021年 / 201卷

基金：

中国国家自然科学基金;

关键词：

Extracellular vesicles; Neurodegenerative diseases; Demyelinating disease; SPINAL-CORD-INJURY; OLIGODENDROCYTE PROGENITOR CELLS; TRAUMATIC BRAIN-INJURY; MICROVASCULAR ENDOTHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; STEM-CELLS; MULTIPLE-SCLEROSIS; ALPHA-SYNUCLEIN; WHITE-MATTER; AMYLOID-BETA;

D O I：

10.1016/j.pneurobio.2021.102022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that arise from the endosome system or directly detach from the plasma membrane. In recent years, many advances have been made in the understanding of the clinical definition and pathogenesis of neurodegenerative diseases, but translation into effective treatments is hampered by several factors. Current research indicates that EVs are involved in the pathology of diseases such as Alzheimer?s disease (AD), Parkinson?s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington?s disease (HD). Besides, EVs are also involved in the process of myelin formation, and can also cross the blood-brain barrier to reach the sites of CNS injury. It is suggested that EVs have great potential as a novel therapy for the treatment of neurodegenerative diseases. Here, we reviewed the advances in understanding the role of EVs in neurodegenerative diseases and addressed the critical function of EVs in the CNS. We have also outlined the physiological mechanisms of EVs in myelin regeneration and highlighted the therapeutic potential of EVs in neurodegenerative diseases.

引用

页数：12

共 238 条

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