Molecular diversity of voltage-gated calcium channels

被引：0

作者：

Lory, P ^{[1
]}

Monteil, A ^{[1
]}

Chemin, J ^{[1
]}

Leuranguer, V ^{[1
]}

Bourinet, E ^{[1
]}

Nargeot, J ^{[1
]}

机构：

[1] CNRS, UPR 1142, IGH, Physiopathol Canaux Ion, F-34396 Montpellier 05, France

来源：

THERAPIE | 2000年 / 55卷 / 02期

关键词：

calcium channels; electrophysiology; alpha(1) subunit; mibefradil; channelopathy;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Voltage-gated calcium channels are involved in a large variety of cellular functions such as excitation-contraction coupling, hormone secretion. firing and pacemaker activity, gene activation and proliferation. Cloning of complementary DNAs encoding for calcium channel subunits has challenged the study of the functional properties of calcium channels and has allowed analysis of the molecular basis of calcium channel diversity. Recently, pore-forming subunits of T-type calcium channels have been cloned. Recent data describing type genes encoding calcium channels, their molecular and pharmacological studies, as well as their linkage to human genetic diseases are reviewed in this article.

引用

页码：249 / 254

页数：6

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