Elevation of serum interleukin-1 receptor antagonist levels in women with gynaecological cancers

被引:16
作者
Fujiwaki, R
Hata, T
Miyazaki, K
Kawamura, T
Inada, K
机构
[1] Shimane Med Univ, Dept Obstet & Gynecol, Izumo, Shimane 693, Japan
[2] Chiyoda Cent Hosp, Dept Obstet & Gynaecol, Chiyoda, Japan
[3] Iwate Med Univ, Dept Anesthesiol, Morioka, Iwate 020, Japan
[4] Iwate Med Univ, Dept Bacteriol, Morioka, Iwate 020, Japan
来源
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1997年 / 104卷 / 12期
关键词
D O I
10.1111/j.1471-0528.1997.tb11012.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This study included 15 patients with gynaecological cancers (7 with cervical cancer, 6 with endometrial cancer, and 12 with ovarian cancer); 7 with benign gynaecological disorders (5 with benign ovarian tumour and 2 with uterine myoma); and 10 healthy women as a control group. Serum interleukin-l receptor antagonist (IL-1 ra) levels in patients with gynaecological cancer were significantly higher than those in patients with benign gynaecological disorders (P = 0.04) and in healthy controls (P = 0.0009). IL-1 ra may play an important role in host immune responses in local and general environments against gynaecological cancers.
引用
收藏
页码:1407 / 1408
页数:2
相关论文
共 6 条
[1]   BIOLOGICAL PROPERTIES OF RECOMBINANT HUMAN MONOCYTE-DERIVED INTERLEUKIN-1 RECEPTOR ANTAGONIST [J].
AREND, WP ;
WELGUS, HG ;
THOMPSON, RC ;
EISENBERG, SP .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1694-1697
[2]  
DINARELLO CA, 1991, BLOOD, V77, P1627
[3]  
GREER IA, 1994, OBSTET GYNECOL, V84, P937
[4]   HIGH-CONCENTRATIONS OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST IN SERUM OF PATIENTS WITH HODGKINS-DISEASE [J].
GRUSS, HJ ;
DOLKEN, G ;
BRACH, MA ;
MERTELSMANN, R ;
HERRMANN, F .
LANCET, 1992, 340 (8825) :968-968
[5]  
ONOZAKI K, 1985, J IMMUNOL, V135, P3962
[6]  
SMITH DR, 1993, AM J PATHOL, V143, P794