Volume, neuron density and total neuron number in five subcortical regions in schizophrenia

被引:139
作者
Kreczmanski, Pawel
Heinsen, Helmut
Mantua, Valentina
Woltersdorf, Fritz
Masson, Thorsten
Ulfig, Norbert
Schmidt-Kastner, Rainald
Korr, Hubert
Steinbusch, Harry W. M.
Hof, Patrick R.
Schmitz, Christoph
机构
[1] Univ Limburg, Dept Psychiat & Neuropsychol, Div Neurosci, NL-6200 MD Maastricht, Netherlands
[2] Univ Limburg, Dept Psychiat & Neuropsychol, Div Cellular Neurosci, NL-6200 MD Maastricht, Netherlands
[3] European Grad Sch Neurosci, Maastricht, Netherlands
[4] Univ Wurzburg, Morphol Brain Res Unit, D-97070 Wurzburg, Germany
[5] Univ Rostock, Dept Anat, D-2500 Rostock, Germany
[6] Rhein Westfal TH Aachen, Dept Anat & Cell Biol, D-5100 Aachen, Germany
[7] Kings Coll London, Inst Psychiat, Dept Psychiat, Sect Clin Neuropharmacol, London WC2R 2LS, England
[8] Univ Roma La Sapienza, Dept Psychiat Sci & Psychol Med, Psychiat Clin 3, I-00161 Rome, Italy
[9] CUNY Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
关键词
amygdala; design-based stereology; schizophrenia; striatum; thalamus;
D O I
10.1093/brain/awl386
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several studies have pointed to alterations in mean volumes, neuron densities and total neuron numbers in the caudate nucleus (CN), putamen, nucleus accumbens (NA), mediodorsal nucleus of the thalamus (MDNT) and lateral nucleus of the amygdala (LNA) in schizophrenia. However, the results of these studies are conflicting and no clear pattern of alterations has yet been established in these subcortical regions, possibly due to differences in quantitative histological methods used as well as differences in the investigated case series. The present study investigates these subcortical regions in both hemispheres of the same post-mortem brains for volume, neuron density and total neuron number with high-precision design-based stereology. The analysed case series consisted of 13 post-mortem brains from male schizophrenic patients [age range: 22-64 years; mean age 51.5 +/- 3.3 years (mean +/- SEM)] and 13 age-matched male controls (age range: 25-65 years; mean age 51.9 +/- 3.1 years). A general linear model multivariate analysis of variance with diagnosis and hemisphere as fixed factors and illness duration (schizophrenic patients) or age (controls), post-mortem interval and fixation time as covariates showed a number of statistically significant alterations in the brains from schizophrenic patients compared with the controls. There was a reduced mean volume of the putamen [-5.0% on the left side (l) and -4.1% on the right side (r)] and the LNA (l: -12.1%, r: -17.6%), and a reduced mean total neuron number in the CN (l: -10.4%, r: -10.2%), putamen (l: -8.1%, r: -11.6%) and the LNA (l: -15.9%, r: -16.2%). These data show a previously unreported, distinct pattern of alterations in mean total neuron numbers in identified subcortical brain regions in a carefully selected sample of brains from schizophrenic patients. The rigorous quantitative analysis of several regions in brains from schizophrenic patients and matched controls is crucial to provide reliable information on the neuropathology of schizophrenia as well as insights about its pathogenesis.
引用
收藏
页码:678 / 692
页数:15
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