Efficient and practical syntheses of a stable labelled form of the non-narcotic analgesic, bicifadine and its metabolites

被引：2
作者：
Chen, Zhengming
Yang, Ji
Little, Gillian
Keats, Andrew
机构：
[1] DOV Pharmaceut Inc, Somerset, NJ 08873 USA
[2] Selcia Ltd, Fyfield Business & Res Pk, Ongar, Essex, England
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2007年 / 50卷 / 1-2期
关键词：
bicifadine; (+/-)-1-(4-methylphenyl)-3-azabiocyclo[3.1.0]hexane; deuterium; DOV 220,075;
D O I：
10.1002/jlcr.1171
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An efficient and practical synthesis of deuterium-labelled bicifadine, together with 3 deuterium-labelled bicifadine metabolites, was developed. The levels of deuterium incorporation are high, and the products were used as internal standards in bioanalytical method development and clinical bioanalysis. Copyright (c) 2007 John Wiley & Sons, Ltd.
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页码：97 / 104
页数：8
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