Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH

被引：46
作者：
Baker, Jacob J. [1 ]
Dechow, Shelby J. [1 ]
Abramovitch, Robert B. [1 ]
机构：
[1] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
来源：
TRENDS IN MICROBIOLOGY | 2019年 / 27卷 / 11期
基金：
美国国家卫生研究院;
关键词：
CHOLESTEROL CATABOLISM; INTRABACTERIAL PH; FATTY-ACIDS; VIRULENCE; PERSISTENCE; STRESS; PHOPR; MICE; GENE; ADAPTATION;
D O I：
10.1016/j.tim.2019.06.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic pH that results in the slowing of bacterial growth and changes in redox homeostasis. It is proposed that induction of the PhoPR regulon and anaplerotic metabolism, in concert with the restricted use of specific carbon sources, functions to counter reductive stress associated with acidic pH.
引用
收藏
页码：942 / 953
页数：12
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