Nuclear imaging potential and in vitro photodynamic activity of symmetrical and asymmetrical zinc phthalocyanines

被引:14
作者
Lambrecht, Fatma Yurt [1 ]
Ocakoglu, Kasim [2 ,3 ]
Er, Ozge [1 ]
Ince, Mine [2 ,3 ]
Gunduz, Cumhur [4 ]
Kayabasi, Cagla [4 ]
机构
[1] Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Bornova, Turkey
[2] Mersin Univ, Adv Technol Res & Applicat Ctr, Ciftlikkoy Campus, TR-33343 Mersin, Yenisehir, Turkey
[3] Mersin Univ, Dept Energy Syst Engn, Fac Tarsus Technol, TR-33480 Mersin, Turkey
[4] Ege Univ, Fac Med, Dept Med Biol, TR-35100 Izmir, Bornova, Turkey
关键词
photodynamic therapy; symmetric phthalocyanine; asymmetric phthalocyanine; I-131; breast cancer cell; 5-AMINOLEVULINIC ACID; THERAPY; BIODISTRIBUTION; DIAGNOSIS; TARGET; PHOTO; I-131;
D O I
10.1002/jlcr.3395
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Photodynamic therapy (PDT) is based on exposing a light-sensitive material that has been localized in target tissues with visible light. In the current study, symmetric Zn(II) octaoctadodecylphthalocyanine (1) and the asymmetrically substituted hydroxyhexyloxy derivative (2) were examined as a multifunctional agent for tumour nuclear imaging and for PDT potential. Zn(II)Pc 1 and Zn(II)Pc 2 were radiolabelled with I-131 using an iodogen method with high efficiency (93.5 +/- 3.5% and 93.0 +/- 2.8%, respectively) under the optimum conditions. Biodistribution study results showed that radiolabelled Zn(II)Pc 1 had a high uptake in the large intestine and unchanging uptake in the ovary. However, radiolabelled Zn(II)Pc 2 uptake was statically significant in the large intestine, pancreas, ovary and lung. For the PDT studies, EMT6/P (mouse mammary cell line) and HeLa (cervical adenocarcinoma cell line) with Zn(II)Pc 1 and Zn(II)Pc 2 were exposed to red light (650nm) at 10-30J/cm(2). Zn(II)Pc 1 and Zn(II)Pc 2 had a good PDT efficacy in the EMT6/P cell line. In conclusion, radiolabelled Zn(II)Pc 1 might be a promising imaging agent for pancreas, ovary and colon tumours. However, the radiolabelled Zn(II)Pc 2 might be a promising nuclear imaging and PDT agent for colon, lung, pancreas and ovary tumours.
引用
收藏
页码:221 / 227
页数:7
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