Complications of chronic pancreatitis in children

被引:10
作者
Perito, Emily [1 ]
Gonska, Tanja [2 ]
Bellin, Melena D. [3 ,4 ]
Schwarzenberg, Sarah Jane [5 ]
机构
[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA
[2] Hosp Sick Children, Div Gastroenterol Hepatol & Nutr, Dept Paediat, Translat Med,Res Inst, Toronto, ON, Canada
[3] Univ Minnesota, Med Ctr, Dept Pediat, Minneapolis, MN 55455 USA
[4] Schulze Diabet Inst, Minneapolis, MN USA
[5] Univ Minnesota, Masonic Childrens Hosp, Dept Pediat, Minneapolis, MN USA
关键词
exocrine pancreatic insufficiency; opioid; pancreatogenic diabetes; INTERNATIONAL STUDY-GROUP; NORTH-AMERICAN SOCIETY; TOTAL PANCREATECTOMY; DIABETES-MELLITUS; ACUTE RECURRENT; ISLET AUTOTRANSPLANTATION; PEDIATRIC PANCREATITIS; POSITION PAPER; CLINICAL PROFILE; MANAGEMENT;
D O I
10.1097/MOG.0000000000000762
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose of review In children, chronic pancreatitis is infrequent but may be associated with serious complications, including severe pain that limits activities, exocrine and endocrine pancreatic insufficiency and malnutrition. Investigation into pediatric chronic pancreatitis has transitioned from single center reports to multicenter, protocol-driven studies. As a result, we now have information on much larger numbers of children with chronic pancreatitis, allowing a more reliable understanding of the complications of chronic pancreatitis. Recent findings A high percentage of children with chronic pancreatitis use opioids frequently to control pain. About a quarter of children with chronic pancreatitis have exocrine pancreatic insufficiency, and about 6% have pancreatogenic diabetes. Mild malnutrition and low bone density are both common in children with chronic pancreatitis. Large multicenter and single-center observational studies have allowed us to more accurately assess complications of chronic pancreatitis in children. These studies demonstrate the need for examination of therapies for these complications in children.
引用
收藏
页码:498 / 503
页数:6
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